Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.360 Biomarker BEFREE NOTCH1 activates the Wnt/β-catenin signaling pathway in colon cancer. 28947978

2017
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.360 AlteredExpression BEFREE Activation of Notch1 converted high-grade adenoma into low-grade adenoma in an Apcmin mouse colon cancer model and suppressed the expression of WNT target genes in human colorectal cancer cells through epigenetic modification recruiting histone methyltransferase SET domain bifurcated 1 (SETDB1). 22863622

2012
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.360 Biomarker BEFREE Conceivably, the modulation of Notch1-related signaling may be a promising therapy for human colon cancers. 20665495

2010
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.360 AlteredExpression BEFREE There is a well-documented association of matrix metalloproteinase-9 (MMP-9) and receptor Notch-1 overexpression in colon cancer. 20068187

2010
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.360 AlteredExpression BEFREE We first show that the Notch-1 receptor, as well as its downstream target Hes-1, is up-regulated with colon cancer progression, similar to other genes involved in chemoresistance. 19147571

2009
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.360 AlteredExpression BEFREE To support this observation, colon cancer cell lines HT29 and SW620 were induced to differentiate in culture, and expression of Notch1 was investigated. 18777195

2009