Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8477
Gene Symbol: GPR65
GPR65
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.020 AlteredExpression BEFREE In contrast with this positive regulation of TAM recruitment, we found no evidence of a direct effect of ERK1/2 signaling on two other important aspects of TAM regulation by GBM cells: (1) the expression of the immune checkpoint ligands PD-L1 and PD-L2, expressed at high mRNA levels in GBM compared with other solid tumors; (2) the production of the tumor metabolite lactate recently reported to dampen tumor immunity by interacting with the receptor GPR65 present on the surface of TAM. 31467175

2019
Entrez Id: 8477
Gene Symbol: GPR65
GPR65
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.020 AlteredExpression BEFREE Our findings suggest that GPR65 is overexpressed in glioblastoma and its high expression predicts unfavorable clinical outcome for patients. 29223793

2018