Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Biomarker BEFREE The observed link between hyperleptinemia and hypogonadism is in line with previous evidence on direct effects of leptin on testosterone production. 28366446

2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 AlteredExpression BEFREE Mice fed IED showed severe hypogonadism with a significant reduction of serum levels of testosterone (-83%) and of luteinizing hormone (-86%), as well as reduced body weight gain, body fat and plasma leptin. 28648620

2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 GeneticVariation BEFREE A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. 20382689

2010
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Biomarker BEFREE Leptin replacement rescues the phenotype of morbid obesity and hypogonadism in leptin-deficient adults. 18854428

2008
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 GeneticVariation BEFREE We have previously demonstrated that genetically based leptin deficiency due to a missense leptin gene mutation in a highly consanguineous extended Turkish pedigree is associated with morbid obesity and hypogonadism. 10523015

1999