This study suggests that both tHcy and the MTHFRC677T gene polymorphism may be important determinants of the incidence of dyslipidemia in Chinese patients with essential hypertension.
The aim of this study was to investigate the association between the MTHFRC677T polymorphism and essential hypertension in a Cameroonian population (Bantu ethnic group) of the South West Region.
Benazepril may cause an increase in plasma Hcy levels among patients with hypertension with low baseline Hcy levels, while effect modification by MTHFRC677T genotypes on the changes in Hcy levels in response to benazepril was not significant among patients with essential hypertension.
Association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and essential hypertension: a systematic review and meta-analysis.
The purpose of this study was to examine the carriage of gene combinations of the ACE (insertion/deletion [I/D]), MTHFR 677T and 1298C, and lipid profiles in patients with essential hypertension (EH) in Turkey.
There was no significant association between MTHFRC677T genotypes and changes in Hcy levels in response to enalapril among subjects with essential hypertension.
In this study, we measured serum folate, serum vitamin B12, and plasma homocysteine and determined the MTHFRC677T genotype of 78 patients with essential hypertension, 100 patients with coronary artery disease, and 100 healthy subjects.
The 677C --> T polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene is associated with elevated homocysteine level in the general population, and therefore it has been hypothesized to be a risk factor for the development of renal failure in the course of essential hypertension.