Conditional knockout (cKO) of <i>FGFR1</i> in the DT (<i>FGFR1<sup>DT-cKO</sup></i> mice) resulted in left ventricular hypertrophy (LVH) and decreased kidney expression of <i>α</i>-Klotho in association with enhanced BP, decreased expression of angiotensin converting enzyme 2, and increased expression of the Na<sup>+</sup>-K<sup>+</sup>-2Cl<sup>-</sup> cotransporter.
Polymorphisms of the angiotensin-converting enzyme 2 (ACE2) gene, which is located on the X chromosome, have been associated with hypertension and left ventricular hypertrophy in previous studies.
Angiotensin-converting enzyme 2 (ACE2) gene has been established to be associated with parameters of left ventricular hypertrophy in community based male subjects.
This study provides evidence that genetic variants in the ACE2 gene may be associated with left ventricular mass, SWT and left ventricular hypertrophy in hemizygous men.