Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE New somatostatin-drug conjugates for effective targeting pancreatic cancer. 30017114

2018

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE Biocompatible single-chain polymer nanoparticles (SCPNs) based on poly(methacrylic acid) were prepared and functionalized with the somatostatin analogue PTR86 as the targeting moiety, since somatostatin receptors are overexpressed in pancreatic cancer. 27608431

2016

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE We propose that SSTR-2 plays an important role in clinical implications for patients with pancreatic cancer undergoing somatostatin or its analog therapy. 25890201

2015

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 GeneticVariation BEFREE These data suggest that SSTR5 P335L is a hypofunctional protein with a potentially harmful effect on function, as well as potential latent effect, and therefore it could affect the clinical response to somatostatin analog therapy for patients with pancreatic cancer. 21249361

2011

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer. 19805200

2009

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE Reexpression of human somatostatin receptor gene 2 gene mediated by oncolytic adenovirus increases antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand against pancreatic cancer. 19671855

2009

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE Functional somatostatin receptors (SSTR) are lost in human pancreatic cancer. 18823376

2008

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE We hypothesize that reintroduction of SSTR genes back into pancreatic cancer cells might be an effective gene therapy strategy for pancreatic cancer. 16183496

2005

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE Reintroduction of SSTR genes has been shown to inhibit pancreatic cancer growth in cell cultures and animal models. 15706439

2005

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 AlteredExpression BEFREE In the current study, we used a powerful real-time RT-PCR technique to examine the mRNA expression levels of all five SSTR subtypes in human pancreatic cancer. 15145694

2004

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE We hypothesized that SSTR2 gene transfer would restore the growth-inhibitory response of human pancreatic cancer to somatostatin. 14572771

2003

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis. 12490654

2003

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE We created adenoviral constructs containing the SSR2 or Lac-Z gene and transfected somatostatin receptor-negative human pancreatic cancer cells (Panc-1). 12069503

2002

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE Transcription of SST2 somatostatin receptor gene in human pancreatic cancer cells is altered by single nucleotide promoter polymorphism. 11208729

2001

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 GeneticVariation BEFREE SW-1990 expressed mRNA for SSTR subtypes 3 and 5, whereas various patterns of subtypes 2A, 3, and 5 were found in other pancreatic cancers. 11555603

2001

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE A subtyping of somatostatin receptors should be carried out before considering a somatostatin analogue treatment in patients with colorectal or pancreatic cancer. 8620499

1996

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.400 Biomarker BEFREE The expression of somatostatin receptors should be considered in the design and interpretation of clinical trials with somatostatin analogs for treatment of pancreatic cancer. 8751588

1996