Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C3203102
Disease: Idiopathic pulmonary arterial hypertension
Idiopathic pulmonary arterial hypertension 		0.060 Biomarker BEFREE <b>Conclusions:</b> Our findings suggest that ACE2 activation attenuates pulmonary vascular remodeling by inducing pulmonary arterial cell apoptosis via Hippo/Yap signaling during the development of PAH. 30806090

2019
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C3203102
Disease: Idiopathic pulmonary arterial hypertension
Idiopathic pulmonary arterial hypertension 		0.060 AlteredExpression BEFREE After confirming reduced plasma ACE2 activity in human PAH, five patients were enrolled in the trial. 29903860

2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C3203102
Disease: Idiopathic pulmonary arterial hypertension
Idiopathic pulmonary arterial hypertension 		0.060 Biomarker BEFREE The AMPK-p-ACE2 S680 axis was also validated in lung tissue from humans with idiopathic pulmonary arterial hypertension. 29570986

2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C3203102
Disease: Idiopathic pulmonary arterial hypertension
Idiopathic pulmonary arterial hypertension 		0.060 Biomarker BEFREE Moreover, magnolol inhibited angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/Ang II type 1 receptor (AT-1R) cascade, whereas upregulates ACE2 in the lungs of PAH rats. 30466619

2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C3203102
Disease: Idiopathic pulmonary arterial hypertension
Idiopathic pulmonary arterial hypertension 		0.060 AlteredExpression BEFREE Moreover, in MVs group, ACE2 mRNA in the lung tissues and plasma levels of Ang-(1-7) were both upregulated compared with PAH group. 29752040

2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C3203102
Disease: Idiopathic pulmonary arterial hypertension
Idiopathic pulmonary arterial hypertension 		0.060 Biomarker BEFREE However, the protective effects of ACE2 activation on PAH were counteracted by co-administration of MLN4760, an ACE2 antagonist (all P > .05). 29146157

2017