Source: CLINVAR

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 CausalMutation CLINVAR Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype. 22808163

2012

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 CausalMutation CLINVAR Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. 22733540

2012

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 CausalMutation CLINVAR Mutations in GNA11 in uveal melanoma. 21083380

2010

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 CausalMutation CLINVAR Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells. 1328859

1992

Entrez Id: 2767
Gene Symbol: GNA11
GNA11
CUI: C0025202
Disease: melanoma
melanoma
0.700 CausalMutation CLINVAR GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. 2549426

1989