Source: CLINVAR

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0025202
Disease: melanoma
melanoma 		0.700 CausalMutation CLINVAR Novel ATP-competitive MEK inhibitor E6201 is effective against vemurafenib-resistant melanoma harboring the MEK1-C121S mutation in a preclinical model. 24448821

2014
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0025202
Disease: melanoma
melanoma 		0.700 CausalMutation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation CLINVAR Phase II trial of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with BRAFV600E/K-mutated melanoma. 23444215

2013
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation CLINVAR Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. 23569304

2013
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0025202
Disease: melanoma
melanoma 		0.700 CausalMutation CLINVAR Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. 23569304

2013
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898

2013
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0025202
Disease: melanoma
melanoma 		0.700 CausalMutation CLINVAR Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors. 22588879

2012
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0025202
Disease: melanoma
melanoma 		0.700 CausalMutation CLINVAR Melanoma genome sequencing reveals frequent PREX2 mutations. 22622578

2012
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0025202
Disease: melanoma
melanoma 		0.700 CausalMutation CLINVAR Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. 21383288

2011
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0025202
Disease: melanoma
melanoma 		0.700 CausalMutation CLINVAR Screening a larger cohort of individuals with melanoma revealed the presence of recurring somatic MAP2K1 and MAP2K2 mutations, which occurred at an overall frequency of 8%. 22197931

2011
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0025202
Disease: melanoma
melanoma 		0.700 CausalMutation CLINVAR COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. 21107320

2010
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation CLINVAR MEK1 mutations confer resistance to MEK and B-RAF inhibition. 19915144

2009
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
CUI: C0025202
Disease: melanoma
melanoma 		0.700 CausalMutation CLINVAR MEK1 mutations confer resistance to MEK and B-RAF inhibition. 19915144

2009