Source: CLINVAR

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3815
Gene Symbol: KIT
KIT
CUI: C0040100
Disease: Thymoma
Thymoma 		0.170 CausalMutation CLINVAR "When a thymic carcinoma ""becomes"" a GIST." 23375402

2013
Entrez Id: 3815
Gene Symbol: KIT
KIT
CUI: C0040100
Disease: Thymoma
Thymoma 		0.170 CausalMutation CLINVAR Activating c-KIT mutations in a subset of thymic carcinoma and response to different c-KIT inhibitors. 22357254

2012
Entrez Id: 3815
Gene Symbol: KIT
KIT
CUI: C0040100
Disease: Thymoma
Thymoma 		0.170 CausalMutation CLINVAR Promising efficacy of sorafenib in a relapsed thymic carcinoma with C-KIT exon 11 deletion mutation. 20970876

2011
Entrez Id: 3815
Gene Symbol: KIT
KIT
CUI: C0040100
Disease: Thymoma
Thymoma 		0.170 CausalMutation CLINVAR Large-scale analysis of KIT aberrations in Chinese patients with melanoma. 21325067

2011
Entrez Id: 3815
Gene Symbol: KIT
KIT
CUI: C0040100
Disease: Thymoma
Thymoma 		0.170 CausalMutation CLINVAR Impressive response with imatinib in a heavily pretreated patient with metastatic c-KIT mutated thymic carcinoma. 21969494

2011
Entrez Id: 3815
Gene Symbol: KIT
KIT
CUI: C0040100
Disease: Thymoma
Thymoma 		0.170 CausalMutation CLINVAR Imatinib upregulates compensatory integrin signaling in a mouse model of gastrointestinal stromal tumor and is more effective when combined with dasatinib. 20736294

2010
Entrez Id: 3815
Gene Symbol: KIT
KIT
CUI: C0040100
Disease: Thymoma
Thymoma 		0.170 CausalMutation CLINVAR Long lasting response to the multikinase inhibitor bay 43-9006 (Sorafenib) in a heavily pretreated metastatic thymic carcinoma. 19461405

2009
Entrez Id: 3815
Gene Symbol: KIT
KIT
CUI: C0040100
Disease: Thymoma
Thymoma 		0.170 CausalMutation CLINVAR Comprehensive genomic analysis reveals clinically relevant molecular distinctions between thymic carcinomas and thymomas. 19861435

2009
Entrez Id: 3815
Gene Symbol: KIT
KIT
CUI: C0040100
Disease: Thymoma
Thymoma 		0.170 CausalMutation CLINVAR Mutational status of EGFR and KIT in thymoma and thymic carcinoma. 18448188

2008
Entrez Id: 3815
Gene Symbol: KIT
KIT
CUI: C0040100
Disease: Thymoma
Thymoma 		0.170 CausalMutation CLINVAR Sorafenib inhibits the imatinib-resistant KITT670I gatekeeper mutation in gastrointestinal stromal tumor. 17699867

2007
Entrez Id: 3815
Gene Symbol: KIT
KIT
CUI: C0040100
Disease: Thymoma
Thymoma 		0.170 CausalMutation CLINVAR L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition. 17372901

2007
Entrez Id: 3815
Gene Symbol: KIT
KIT
CUI: C0040100
Disease: Thymoma
Thymoma 		0.170 CausalMutation CLINVAR Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. 15930355

2005
Entrez Id: 3815
Gene Symbol: KIT
KIT
CUI: C0040100
Disease: Thymoma
Thymoma 		0.170 CausalMutation CLINVAR Thymic carcinoma with overexpression of mutated KIT and the response to imatinib. 15201427

2004
Entrez Id: 3815
Gene Symbol: KIT
KIT
CUI: C0040100
Disease: Thymoma
Thymoma 		0.170 CausalMutation CLINVAR Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior: KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors. 12960119

2003