×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Chronic Lymphocytic Leukemia
0.800
SomaticCausalMutation
ORPHANET
A microRNA/TP53 feedback circuitry is associated with CLL pathogenesis and outcome.
21205967 2011
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Chronic Lymphocytic Leukemia
0.800
SomaticCausalMutation
ORPHANET
Recurrent losses or gains of genomic material as well as mutations of key tumor suppressors (ATM and TP53 ) have been identified in chronic lymphocytic leukemia (CLL ).
21435757 2011
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Chronic Lymphocytic Leukemia
0.800
SomaticCausalMutation
ORPHANET
Our findings add a new aspect to the mosaic of the p53 mutability in B-CLL .
17920683 2008
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Chronic Lymphocytic Leukemia
0.800
Biomarker
CTD_human
The induction of p53 by nutlin-3 in B-CLL samples was accompanied by alterations of the mitochondrial potential and activation of the caspase-dependent apoptotic pathway.
16439677 2006
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Chronic Lymphocytic Leukemia
0.800
SomaticCausalMutation
ORPHANET
Translocations or isochromosome formations at sites of low-copy DNA repeats in 17p10 to 17p12 appear to be the mechanism for the loss of TP53 in B-CLL .
16737921 2006
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Chronic Lymphocytic Leukemia
0.800
SomaticCausalMutation
ORPHANET
New translocations in a case of atypical B-cell chronic lymphocytic leukemia : involvement of ATM, MLL, and TP53 genes.
16938579 2006
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Chronic Lymphocytic Leukemia
0.800
CausalMutation
CGI
×
Entrez Id: 5336
Gene Symbol: PLCG2
PLCG2
Chronic Lymphocytic Leukemia
0.700
Biomarker
CTD_human
We suggest that R665W and L845F be referred to as allomorphic rather than hypermorphic mutations of PLCG2 Rerouting of the transmembrane signals emanating from BCR and converging on PLCγ<sub>2</sub> through Rac in ibrutinib-resistant CLL cells may provide novel drug treatment strategies to overcome ibrutinib resistance mediated by PLCG2 mutations or to prevent its development in ibrutinib-treated CLL patients.
27542411 2016
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Chronic Lymphocytic Leukemia
0.700
Biomarker
CTD_human
CLL with 11q deletion can be divided into two subgroups based on the integrity of the residual ATM allele.17968022 2007
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Chronic Lymphocytic Leukemia
0.700
SomaticCausalMutation
ORPHANET
In five B-CLL s and one MCL with deletion of one ATM allele, a point mutation in the remaining allele was detected, which resulted in aberrant transcript splicing, alteration, or truncation of the protein.
10397742 1999
×
Entrez Id: 5336
Gene Symbol: PLCG2
PLCG2
Chronic Lymphocytic Leukemia
0.700
CausalMutation
CGI
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Chronic Lymphocytic Leukemia
0.700
GeneticVariation
UNIPROT
×
Entrez Id: 25913
Gene Symbol: POT1
POT1
Chronic Lymphocytic Leukemia
0.640
SomaticCausalMutation
ORPHANET
The identification of POT1 as a new frequently mutated gene in CLL may facilitate novel approaches for the clinical management of this disease.
23502782 2013
×
Entrez Id: 25913
Gene Symbol: POT1
POT1
Chronic Lymphocytic Leukemia
0.640
CausalMutation
CGI
IGHV3-21
Chronic Lymphocytic Leukemia
0.600
Biomarker
ORPHANET
Clinically, co-occurrence of SF3B1 mutations and subset 2 BCR configuration prompts disease progression in IGHV3-21 -CLL , whereas cooperation between NOTCH1 mutations, +12, and subset 8 BCR configuration invariably primes CLL transformation into Richter syndrome.
23637131 2013
IGHV3-21
Chronic Lymphocytic Leukemia
0.600
Biomarker
ORPHANET
To investigate the IGHV3-21 frequency and the clinical impact of IGHV3-21 stereotypy, 337 newly diagnosed Swedish CLL patients from a population-based cohort were analyzed.
22464020 2012
IGHV3-21
Chronic Lymphocytic Leukemia
0.600
Biomarker
ORPHANET
T-cell independent, B-cell receptor-mediated induction of telomerase activity differs among IGHV mutation-based subgroups of chronic lymphocytic leukemia patients.
22875913 2012
IGHV3-21
Chronic Lymphocytic Leukemia
0.600
Biomarker
ORPHANET
IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells.
21372840 2011
IGHV3-21
Chronic Lymphocytic Leukemia
0.600
Biomarker
CTD_human
Distinctive gene expression pattern in VH3-21 utilizing B-cell chronic lymphocytic leukemia.
15817677 2005
×
Entrez Id: 5027
Gene Symbol: P2RX7
P2RX7
Chronic Lymphocytic Leukemia
0.590
Biomarker
ORPHANET
We investigated tumour DNA in 170 patients with CLL using PCR-RFLP analysis with HhaI restriction enzyme cleavage to screen for the polymorphism in the P2X7 receptor gene.
12493261 2002
×
Entrez Id: 5027
Gene Symbol: P2RX7
P2RX7
Chronic Lymphocytic Leukemia
0.590
Biomarker
CTD_human
Expression of P2X(7) purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X(7) receptors.
11003599 2000
×
Entrez Id: 596
Gene Symbol: BCL2
BCL2
Chronic Lymphocytic Leukemia
0.500
Biomarker
CTD_human
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
23770605 2013
×
Entrez Id: 51176
Gene Symbol: LEF1
LEF1
Chronic Lymphocytic Leukemia
0.500
Biomarker
CTD_human
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
23770605 2013
×
Entrez Id: 23451
Gene Symbol: SF3B1
SF3B1
Chronic Lymphocytic Leukemia
0.500
Biomarker
CTD_human
Further analysis in 279 individuals with CLL showed that SF3B1 mutations were associated with faster disease progression and poor overall survival.
22158541 2011
×
Entrez Id: 596
Gene Symbol: BCL2
BCL2
Chronic Lymphocytic Leukemia
0.500
Biomarker
CTD_human
Resistance to therapy in CLL depends on the expression and activity of anti-apoptotic proteins of the Bcl-2 family.
21750559 2011