×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Small cell carcinoma of lung
0.720
SomaticCausalMutation
ORPHANET
Comprehensive genomic profiles of small cell lung cancer.
26168399 2015
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Small cell carcinoma of lung
0.720
Biomarker
CTD_human
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.
22941189 2012
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Small cell carcinoma of lung
0.720
Biomarker
CTD_human
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.
22941188 2012
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Small cell carcinoma of lung
0.720
CausalMutation
CGI
×
Entrez Id: 5925
Gene Symbol: RB1
RB1
Small cell carcinoma of lung
0.720
GenomicAlterations
CGI
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Small cell carcinoma of lung
0.700
SomaticCausalMutation
ORPHANET
Comprehensive genomic profiles of small cell lung cancer.
26168399 2015
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Small cell carcinoma of lung
0.700
Biomarker
CTD_human
Finally, we detected many of the alterations found in humans in SCLC tumors from Tp53 and Rb1 double knockout mice.
22941188 2012
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Small cell carcinoma of lung
0.700
Biomarker
CTD_human
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.
22941189 2012
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Small cell carcinoma of lung
0.500
Biomarker
CTD_human
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.
22941188 2012
×
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
Small cell carcinoma of lung
0.400
Biomarker
CTD_human
The importance of ASCL1 as a potential driver oncogene in SCLC is further underscored by the observation that ASCL1 is overexpressed in >50% of SCLC specimens, an extent greater than that observed for other putative oncogenes (MYC, MYCN, and SOX2) previously implicated in SCLC .
26253517 2015
×
Entrez Id: 6597
Gene Symbol: SMARCA4
SMARCA4
Small cell carcinoma of lung
0.400
Biomarker
CTD_human
SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies transcriptionally related to BAF-deficient sarcomas.
26343384 2015
×
Entrez Id: 3642
Gene Symbol: INSM1
INSM1
Small cell carcinoma of lung
0.400
Biomarker
CTD_human
Selective inhibition of tumor oncogenes by disruption of super-enhancers.
23582323 2013
×
Entrez Id: 4610
Gene Symbol: MYCL
MYCL
Small cell carcinoma of lung
0.400
Therapeutic
CTD_human
Silencing of MYCL1 in SCLC cell lines that had the RLF-MYCL1 fusion decreased cell proliferation.
22941189 2012
×
Entrez Id: 6657
Gene Symbol: SOX2
SOX2
Small cell carcinoma of lung
0.400
Biomarker
CTD_human
Suppression of SOX2 using shRNAs blocked proliferation of SOX2 -amplified SCLC lines.
22941189 2012
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Small cell carcinoma of lung
0.400
Biomarker
CTD_human
Further comparative molecular analysis of these histologically distinct tumors would be of value to better understand the potential role of EGFR in the pathogenesis of SCLC in never-smokers, and the role of selection for an EGFR -mutant SCLC subclone as an unusual mechanism of acquired resistance to EGFR inhibitors in NSCLC.
20837450 2010
×
Entrez Id: 3815
Gene Symbol: KIT
KIT
Small cell carcinoma of lung
0.400
Biomarker
CTD_human
The level of c-kit mRNA expression was variable in SCLC tumors (positive for 2 of 4 xenografts), and c-kit protein was not detected by immunohistochemistry.
15499612 2005
×
Entrez Id: 551
Gene Symbol: AVP
AVP
Small cell carcinoma of lung
0.390
Biomarker
CTD_human
Potentiation of small cell lung cancer-related SIADH by trifluoperazine.
2832203 1987
×
Entrez Id: 207
Gene Symbol: AKT1
AKT1
Small cell carcinoma of lung
0.390
CausalMutation
CGI
×
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
Small cell carcinoma of lung
0.380
Biomarker
CTD_human
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.
22941188 2012
×
Entrez Id: 1993
Gene Symbol: ELAVL2
ELAVL2
Small cell carcinoma of lung
0.350
Biomarker
CTD_human
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.
22941189 2012
×
Entrez Id: 1387
Gene Symbol: CREBBP
CREBBP
Small cell carcinoma of lung
0.330
Biomarker
CTD_human
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.
22941188 2012
×
Entrez Id: 8570
Gene Symbol: KHSRP
KHSRP
Small cell carcinoma of lung
0.310
Biomarker
CTD_human
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.
22941189 2012
TMEM132D
Small cell carcinoma of lung
0.310
Biomarker
CTD_human
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.
22941189 2012
×
Entrez Id: 9425
Gene Symbol: CDYL
CDYL
Small cell carcinoma of lung
0.310
Biomarker
CTD_human
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.
22941189 2012
×
Entrez Id: 9353
Gene Symbol: SLIT2
SLIT2
Small cell carcinoma of lung
0.310
Biomarker
CTD_human
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.
22941188 2012