Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.100 GeneticVariation BEFREE We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the S18Y polymorphism of the UCH-L1 gene. 11782995

2002
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation BEFREE Our finding suggests that this BDNF-gene Val66Met polymorphism may be related to schizophrenia pathogenesis in patients responsive to clozapine treatment. 12951204

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.100 GeneticVariation BEFREE The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with MDD, its clinical manifestations, and antidepressant response. 14582140

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.100 GeneticVariation BEFREE The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects. 14673216

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.100 GeneticVariation BEFREE This study has examined the association between the BDNF gene Val66Met polymorphism and mood disorders, age of onset and suicidal behavior in a Chinese sample population. 14673216

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.100 GeneticVariation BEFREE Thus, our negative findings suggest that it is unlikely that the BDNF Val66Met polymorphism plays a major role in the pathogenesis of PD in the Chinese population. 14642442

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.100 GeneticVariation BEFREE The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects. 14673216

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.100 GeneticVariation BEFREE The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects. 14673216

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder 		0.090 GeneticVariation BEFREE There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD. 12524161

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia 		0.070 GeneticVariation BEFREE There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD. 12524161

2003
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.100 GeneticVariation BEFREE Our negative findings suggest that it is unlikely that the BDNF Val66Met polymorphism plays a major role in the pathogenesis of AD in the Chinese population and do not support previous findings that homozygosity for the 66Val allele confers an increased risk for AD. 14730194

2004
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.100 GeneticVariation BEFREE A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. 15537879

2004
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.100 GeneticVariation BEFREE The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population. 15336520

2004
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.100 GeneticVariation BEFREE We estimated and compared the haplotype frequencies between C270T and G196A markers in PD and controls that was positive (p = 0.0019). 15120095

2004
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.100 GeneticVariation BEFREE A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. 15537879

2004
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation BEFREE Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. 15543516

2004
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.100 GeneticVariation BEFREE Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. 15543516

2004
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.080 GeneticVariation BEFREE We previously reported a strong association of the Met66 allele of the Val66Met BDNF variant with restricting AN (ANR) and low minimum body mass index in Spanish patients. 15115760

2004
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0013473
Disease: Eating Disorders
Eating Disorders 		0.070 GeneticVariation BEFREE This study suggests that the BDNF 196G/A gene polymorphism might be associated with a susceptibility to eating disorders. 15108194

2004
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		0.060 GeneticVariation BEFREE The present study tested the hypothesis that the BDNF gene Val66Met polymorphism is associated with panic disorder. 15118353

2004
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C3714760
Disease: Drug-induced tardive dyskinesia
Drug-induced tardive dyskinesia 		0.050 GeneticVariation BEFREE We concluded that the BDNF val66met genetic polymorphism may exert its effect on the clinically phenotypic variability after TD has occurred. 15626824

2004
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0686347
Disease: Tardive Dyskinesia
Tardive Dyskinesia 		0.050 GeneticVariation BEFREE We concluded that the BDNF val66met genetic polymorphism may exert its effect on the clinically phenotypic variability after TD has occurred. 15626824

2004
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1970943
Disease: MAJOR AFFECTIVE DISORDER 4
MAJOR AFFECTIVE DISORDER 4 		0.010 GeneticVariation BEFREE Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. 15543516

2004
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C2700439
Disease: MAJOR AFFECTIVE DISORDER 8
MAJOR AFFECTIVE DISORDER 8 		0.010 GeneticVariation BEFREE Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. 15543516

2004
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C1970945
Disease: MAJOR AFFECTIVE DISORDER 6
MAJOR AFFECTIVE DISORDER 6 		0.010 GeneticVariation BEFREE Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. 15543516

2004