Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 GeneticVariation BEFREE <i>BDNF</i> gene Val66Met variation may be associated with cognitive deficits in T2DM, especially with delayed memory. 29423073

2018
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders 		0.020 GeneticVariation BEFREE <i>BDNF</i> gene Val66Met variation may be associated with cognitive deficits in T2DM, especially with delayed memory. 29423073

2018
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.020 GeneticVariation BEFREE <i>BDNF</i> gene Val66Met variation may be associated with cognitive deficits in T2DM, especially with delayed memory. 29423073

2018
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.100 GeneticVariation BEFREE 5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and plasticity of circuitries of emotion processing. 18347599

2008
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.100 GeneticVariation BEFREE 5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and plasticity of circuitries of emotion processing. 18347599

2008
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.100 GeneticVariation BEFREE 5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and plasticity of circuitries of emotion processing. 18347599

2008
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0154575
Disease: Rumination Disorders
Rumination Disorders 		0.030 GeneticVariation BEFREE Rumination may be an endophenotype in the pathway from the BDNF Val66Met polymorphism to depression. 17959306

2007
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0917801
Disease: Sleeplessness
Sleeplessness 		0.030 GeneticVariation BEFREE Insomnia and decreased sexual desire, side effects of fluoxetine, may have an association with the BDNF Val66Met polymorphism, and Met allele carriers showed a lower incidence of these side effects. 20016225

2010
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0008060
Disease: child abuse behavior
child abuse behavior 		0.020 GeneticVariation BEFREE Child abuse may moderate Val66Met's impact on threat reactivity. 29649711

2018
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.100 GeneticVariation BEFREE Val66Met polymorphism of the BDNF gene may be associated with cognitive performance on the WCST in bipolar mood disorder but not in schizophrenia. 16472361

2006
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation BEFREE Val66Met polymorphism of the BDNF gene may be associated with cognitive performance on the WCST in bipolar mood disorder but not in schizophrenia. 16472361

2006
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.100 GeneticVariation BEFREE G196A, a common polymorphism of the BDNF gene, not only affects cognitive and motor processes, but also is associated with various psychiatric disorders. 20085561

2010
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.100 GeneticVariation BEFREE G196A, a common polymorphism of the BDNF gene, not only affects cognitive and motor processes, but also is associated with various psychiatric disorders. 20085561

2010
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.100 GeneticVariation BEFREE G196A polymorphism is not a risk factor for PD and does not seem to modify clinical features in PD patients studied here. 20085561

2010
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0025193
Disease: Melancholia
Melancholia 		0.020 GeneticVariation BEFREE Val66Met BDNF genotypes in melancholic depression: effects on brain structure and treatment outcome. 23165919

2013
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.100 GeneticVariation BEFREE Val66Met polymorphism and serum brain-derived neurotrophic factor in bipolar disorder: an open-label trial. 23957567

2014
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents 		0.020 GeneticVariation BEFREE Val66Met BDNF gene polymorphism influences human motor cortex plasticity in acute stroke. 25241287

2015
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0393593
Disease: Dystonia Disorders
Dystonia Disorders 		0.030 GeneticVariation BEFREE Val66Met polymorphism of brain-derived neurotrophic factor is associated with idiopathic dystonia. 25523127

2015
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0013421
Disease: Dystonia
Dystonia 		0.030 GeneticVariation BEFREE Val66Met polymorphism of brain-derived neurotrophic factor is associated with idiopathic dystonia. 25523127

2015
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.100 GeneticVariation BEFREE Val66Met variation was not associated with OCD or GAD. 26209750

2015
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0270549
Disease: Generalized Anxiety Disorder
Generalized Anxiety Disorder 		0.050 GeneticVariation BEFREE Val66Met variation was not associated with OCD or GAD. 26209750

2015
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.100 GeneticVariation BEFREE Val66Met (also known as rs6265 or G196A), the only known functional polymorphism of the BDNF gene, has been widely studied and considered to be associated with risk of some psychiatric disorders such as bipolar disorder and schizophrenia. 26503495

2015
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.100 GeneticVariation BEFREE Val66Met (also known as rs6265 or G196A), the only known functional polymorphism of the BDNF gene, has been widely studied and considered to be associated with risk of some psychiatric disorders such as bipolar disorder and schizophrenia. 26503495

2015
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.100 GeneticVariation BEFREE Val66Met (also known as rs6265 or G196A), the only known functional polymorphism of the BDNF gene, has been widely studied and considered to be associated with risk of some psychiatric disorders such as bipolar disorder and schizophrenia. 26503495

2015
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.040 GeneticVariation BEFREE Val66Met BDNF polymorphism as a vulnerability factor for inflammation-associated depressive symptoms in women with breast cancer. 26967918

2016