Source: GWASDB

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10468017
rs10468017
ALDH1A2
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.890 GeneticVariation GWASDB Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. 21665990

2011
dbSNP: rs10468017
rs10468017
ALDH1A2
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.890 GeneticVariation GWASDB Our LIPC association was strongest for a functional promoter variant, rs10468017, (P = 1.34e-08), that influences LIPC expression and serum HDL levels with a protective effect of the minor T allele (HDL increasing) for advanced wet and dry AMD. 20385826

2010
dbSNP: rs493258
rs493258
ALDH1A2
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		C 0.860 GeneticVariation GWASDB Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010
dbSNP: rs493258
rs493258
ALDH1A2
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		C 0.860 GeneticVariation GWASDB Our discovery data implicated the association between AMD and a variant in the hepatic lipase gene (LIPC) in the high-density lipoprotein cholesterol (HDL) pathway (discovery P = 4.53e-05 for rs493258). 20385826

2010
dbSNP: rs920915
rs920915
ALDH1A2
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.810 GeneticVariation GWASDB Seven new loci associated with age-related macular degeneration. 23455636

2013
dbSNP: rs3784262
rs3784262
ALDH1A2
CUI: C0004763
Disease: Barrett Esophagus
Barrett Esophagus 		A 0.820 GeneticVariation GWASDB A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790

2013
dbSNP: rs261332
rs261332
LIPC ; ALDH1A2 ; LIPC-AS1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.700 GeneticVariation GWASDB Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. 18179892

2008
dbSNP: rs1800588
rs1800588
LIPC ; ALDH1A2
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.720 GeneticVariation GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282

2011
dbSNP: rs4775041
rs4775041
ALDH1A2
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.700 GeneticVariation GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282

2011
dbSNP: rs1532085
rs1532085
ALDH1A2
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.700 GeneticVariation GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282

2011
dbSNP: rs10468017
rs10468017
ALDH1A2
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.700 GeneticVariation GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282

2011
dbSNP: rs1532085
rs1532085
ALDH1A2
CUI: C4528257
Disease: Corpuscular Hemoglobin Concentration Mean
Corpuscular Hemoglobin Concentration Mean 		G 0.700 GeneticVariation GWASDB Seventy-five genetic loci influencing the human red blood cell. 23222517

2012
dbSNP: rs10468017
rs10468017
ALDH1A2
CUI: C4528257
Disease: Corpuscular Hemoglobin Concentration Mean
Corpuscular Hemoglobin Concentration Mean 		0.700 GeneticVariation GWASDB Seventy-five genetic loci influencing the human red blood cell. 23222517

2012
dbSNP: rs8034802
rs8034802
LIPC ; ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs8034802
rs8034802
LIPC ; ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations. 23236364

2012
dbSNP: rs588136
rs588136
LIPC ; ALDH1A2 ; LIPC-AS1
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs4775041
rs4775041
ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project. 22629316

2012
dbSNP: rs4775041
rs4775041
ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		C 0.800 GeneticVariation GWASDB Newly identified loci that influence lipid concentrations and risk of coronary artery disease. 18193043

2008
dbSNP: rs4775041
rs4775041
ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs261342
rs261342
LIPC ; ALDH1A2 ; LIPC-AS1
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs261336
rs261336
LIPC ; ALDH1A2 ; LIPC-AS1
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs261334
rs261334
LIPC ; ALDH1A2 ; LIPC-AS1
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		G 0.800 GeneticVariation GWASDB Genetic variants influencing circulating lipid levels and risk of coronary artery disease. 20864672

2010
dbSNP: rs261332
rs261332
LIPC ; ALDH1A2 ; LIPC-AS1
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs2070895
rs2070895
LIPC ; ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs2070895
rs2070895
LIPC ; ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project. 22629316

2012