Source: GWASDB

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10468017
rs10468017
ALDH1A2
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.890 GeneticVariation GWASDB Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. 21665990

2011
dbSNP: rs10468017
rs10468017
ALDH1A2
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.890 GeneticVariation GWASDB Our LIPC association was strongest for a functional promoter variant, rs10468017, (P = 1.34e-08), that influences LIPC expression and serum HDL levels with a protective effect of the minor T allele (HDL increasing) for advanced wet and dry AMD. 20385826

2010
dbSNP: rs493258
rs493258
ALDH1A2
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		C 0.860 GeneticVariation GWASDB Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010
dbSNP: rs493258
rs493258
ALDH1A2
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		C 0.860 GeneticVariation GWASDB Our discovery data implicated the association between AMD and a variant in the hepatic lipase gene (LIPC) in the high-density lipoprotein cholesterol (HDL) pathway (discovery P = 4.53e-05 for rs493258). 20385826

2010
dbSNP: rs3784262
rs3784262
ALDH1A2
CUI: C0004763
Disease: Barrett Esophagus
Barrett Esophagus 		A 0.820 GeneticVariation GWASDB A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790

2013
dbSNP: rs920915
rs920915
ALDH1A2
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.810 GeneticVariation GWASDB Seven new loci associated with age-related macular degeneration. 23455636

2013
dbSNP: rs10468017
rs10468017
ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs10468017
rs10468017
ALDH1A2
CUI: C0202177
Disease: Phospholipid measurement
Phospholipid measurement 		0.800 GeneticVariation GWASDB Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. 22359512

2012
dbSNP: rs10468017
rs10468017
ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks. 21589926

2011
dbSNP: rs10468017
rs10468017
ALDH1A2
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		C 0.800 GeneticVariation GWASDB A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. 21386085

2011
dbSNP: rs10468017
rs10468017
ALDH1A2
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		0.800 GeneticVariation GWASDB Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. 19060911

2009
dbSNP: rs10468017
rs10468017
ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		T 0.800 GeneticVariation GWASDB Common variants at 30 loci contribute to polygenic dyslipidemia. 19060906

2009
dbSNP: rs1077835
rs1077835
LIPC ; ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. 23505323

2013
dbSNP: rs1532085
rs1532085
ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		A 0.800 GeneticVariation GWASDB Discovery and refinement of loci associated with lipid levels. 24097068

2013
dbSNP: rs1532085
rs1532085
ALDH1A2
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement 		0.800 GeneticVariation GWASDB Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels. 24023260

2013
dbSNP: rs1532085
rs1532085
ALDH1A2
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		A 0.800 GeneticVariation GWASDB Discovery and refinement of loci associated with lipid levels. 24097068

2013
dbSNP: rs1532085
rs1532085
ALDH1A2
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement 		A 0.800 GeneticVariation GWASDB Discovery and refinement of loci associated with lipid levels. 24097068

2013
dbSNP: rs1532085
rs1532085
ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012
dbSNP: rs1532085
rs1532085
ALDH1A2
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		G 0.800 GeneticVariation GWASDB Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527

2012
dbSNP: rs1532085
rs1532085
ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks. 21589926

2011
dbSNP: rs1532085
rs1532085
ALDH1A2
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement 		G 0.800 GeneticVariation GWASDB Biological, clinical and population relevance of 95 loci for blood lipids. 20686565

2010
dbSNP: rs1532085
rs1532085
ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		A 0.800 GeneticVariation GWASDB Biological, clinical and population relevance of 95 loci for blood lipids. 20686565

2010
dbSNP: rs1532085
rs1532085
ALDH1A2
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		G 0.800 GeneticVariation GWASDB Biological, clinical and population relevance of 95 loci for blood lipids. 20686565

2010
dbSNP: rs1532085
rs1532085
ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		A 0.800 GeneticVariation GWASDB Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. 19060910

2009
dbSNP: rs1532085
rs1532085
ALDH1A2
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		G 0.800 GeneticVariation GWASDB Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. 19060911

2009