|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. European Multicentre Association Study of Schizophrenia (EMASS) Group.
|
8622505 |
1996 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A statistically significant association between a silent mutation (102T/C) in the serotonin-2A (5-HT2A) receptor gene and schizophrenia has recently been reported in a sample of Japanese patients and healthy controls.
|
8655141 |
1996 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings are consistent with other recent association studies which argue against the involvement of the 5-HT2a/T102C polymorphism in predisposition to schizophrenia.
|
9259371 |
1997 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data do not support an allelic association between the 102T/C polymorphism of the 5-HT2A receptor gene and schizophrenia in Chinese population.
|
9264136 |
1997 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although association studies between MspI polymorphism (T102C) and the 5-HT2a receptor gene and schizophrenia have been reported, their results are still controversial.
|
9694252 |
1998 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies have also shown an association between the allele C of 102T/C polymorphism in the 5-HT2A receptor gene and schizophrenia.
|
10686553 |
2000 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we investigated the potential influence of the T102C polymorphism on the psychopathology of schizophrenia.
|
10686558 |
2000 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a 5-HT2A receptor gene T102C polymorphism has been reported to be associated with clinical response to 5-HT2A receptor antagonist in patients with schizophrenia, suggesting this polymorphism of the gene affects the 5-HT2A receptor function.
|
10781645 |
2000 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three polymorphisms in HTR2A, one silent (C102T), one that alters the amino acid sequence (his452tyr) and one in the promoter region (A-1437G) were investigated in 136 patients refractory or intolerant to treatment with typical antipsychotics and with a DSM-IIIR diagnosis of schizophrenia.
|
11317228 |
2001 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Case-control association studies have identified the T102C polymorphism of the 5-HT2A receptor gene as being associated with schizophrenia and responsiveness to clozapine.
|
11526996 |
2001 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The data from Kuwaiti Arabs (although our sample size is relatively small) support the findings from some other populations (Caucasians, Japanese), in which a lack of association has been found between T102C polymorphism and the onset of schizophrenia.
|
12109966 |
2002 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings indicate that the T102C polymorphisms of the 5-HT2A receptor gene does not play a substantial role in schizophrenia nor help evaluate susceptibility to schizophrenia.
|
12606842 |
2003 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the meta-analysis of 31 case-control association studies, we found a significant association between the C allele of the T102C polymorphism and schizophrenia, which was more pronounced in European samples than in the entire sample.
|
14741324 |
2004 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Another 5-HT(2A) receptor polymorphism consists of the silent thymidine-cytosine substitution (102T>C), which has been controversially associated with schizophrenia.
|
15037867 |
2004 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These data did not provide evidence for a contribution of the 102T/C SNP of HTR2A gene to susceptibility to the southern Han Chinese schizophrenia.
|
15048642 |
2004 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of this study did not demonstrate a robust association of the allele C of the T102C HTR2A polymorphism with lifetime or current suicidality in patients with schizophrenia.
|
15469201 |
2004 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analyses of pooled ORs support association of schizophrenia to the Ser311Cys polymorphism in DRD2 and the T102C polymorphism in HTR2A, and of attention deficit hyperactivity disorder to the 48-bp repeat in DRD4.
|
15802092 |
2005 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies suggest that the 5-hydroxytryptamine receptor 2A (5-HT2A) gene (HTR2A) T102C and G-1438A polymorphisms may influence treatment response of risperidone or olanzapine for schizophrenia's negative symptoms (e.g., blunted affect and social withdrawal).
|
15882132 |
2005 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We detected 7 single nucleotide polymorphisms (SNPs) on 13q14, one (rs6313) present at the HTR2A locus and the other 6 at the KPNA3 locus, among 124 British family trios consisting of mother, father and affected offspring with schizophrenia.
|
15882913 |
2005 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We performed primer extension assays to measure relative expression of allele-specific HTR2A transcripts in mRNAs isolated from the prefrontal cortex of 31 individuals with schizophrenia and from peripheral lymphocytes (PBLs) of 31 healthy individuals heterozygous for 102T/C.
|
17069769 |
2006 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Differential expression and parent-of-origin effect of the 5-HT2A receptor gene C102T polymorphism: analysis of suicidality in schizophrenia and bipolar disorder.
|
17221840 |
2007 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between the T102C polymorphism on the 5HT2A gene and cognitive function as well as clinical manifestations in patients with schizophrenia.
|
17221846 |
2007 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our replication study provides further evidence for association between the 5-HTR2A receptor T102C polymorphism and schizophrenia.
|
17240119 |
2007 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate (i) the association between four serotonergic polymorphisms (A-1438G and T102C of the 5-HT2A receptor gene, and 5-HTT VNTR and 5-HTTLPR of the 5-HT transporter gene) and schizophrenia and (ii) the potential interaction of those polymorphisms in the development of schizophrenia.
|
17291660 |
2007 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no genetic association between HTR2A T102C with either schizophrenia or bipolar disorder under the assumption of a parent-of-origin effect, and these data together essentially exclude imprinting at this locus as a potential explanation for the complex inheritance observed in major psychoses.
|
17407792 |
2007 |