|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A statistically significant association between a silent mutation (102T/C) in the serotonin-2A (5-HT2A) receptor gene and schizophrenia has recently been reported in a sample of Japanese patients and healthy controls.
|
8655141 |
1996 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although association studies between MspI polymorphism (T102C) and the 5-HT2a receptor gene and schizophrenia have been reported, their results are still controversial.
|
9694252 |
1998 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Another 5-HT(2A) receptor polymorphism consists of the silent thymidine-cytosine substitution (102T>C), which has been controversially associated with schizophrenia.
|
15037867 |
2004 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. European Multicentre Association Study of Schizophrenia (EMASS) Group.
|
8622505 |
1996 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between T102C and A-1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs.
|
17617023 |
2007 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Case-control association studies have identified the T102C polymorphism of the 5-HT2A receptor gene as being associated with schizophrenia and responsiveness to clozapine.
|
11526996 |
2001 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Could HTR2A T102C and DRD3 Ser9Gly predict clinical improvement in patients with acutely exacerbated schizophrenia? Results from treatment responses to risperidone in a naturalistic setting.
|
17924589 |
2008 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Cytosine methylation of HTR2A at T102C polymorphic site in DNA derived from the saliva can potentially be used as a diagnostic, prognostic, and/or therapeutic biomarker in SCZ and BD.
|
21598376 |
2011 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Differential expression and parent-of-origin effect of the 5-HT2A receptor gene C102T polymorphism: analysis of suicidality in schizophrenia and bipolar disorder.
|
17221840 |
2007 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Forty-nine patients, with schizophrenia or schizoaffective disorder and treated with clozapine (n = 22) or olanzapine (n = 27), were evaluated for fasting levels of C-peptide, insulin and blood glucose, homeostasis model assessment index for insulin resistance (HOMA-IR) and body mass index (BMI), and genotyped for the -1438A/G, -783A/G, 102T/C, and His452Tyr polymorphisms of the HTR2A gene.
|
20521326 |
2010 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a further analysis by ethnicity, the OR and 95% CIs indicated the T102C polymorphism was not associated with MDD, BPD, or SCZ in Caucasian, Asian or Chinese populations.
|
24962835 |
2014 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our replication study provides further evidence for association between the 5-HTR2A receptor T102C polymorphism and schizophrenia.
|
17240119 |
2007 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the meta-analysis of 31 case-control association studies, we found a significant association between the C allele of the T102C polymorphism and schizophrenia, which was more pronounced in European samples than in the entire sample.
|
14741324 |
2004 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we investigated the potential influence of the T102C polymorphism on the psychopathology of schizophrenia.
|
10686558 |
2000 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interestingly, promoter DNA of HTR2A was hypermethylated at and around the -1438A/G polymorphic site, but was hypomethylated at and around T102C polymorphic site in SCZ and BD compared to the controls.
|
21550210 |
2011 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analyses of pooled ORs support association of schizophrenia to the Ser311Cys polymorphism in DRD2 and the T102C polymorphism in HTR2A, and of attention deficit hyperactivity disorder to the 48-bp repeat in DRD4.
|
15802092 |
2005 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data do not support an allelic association between the 102T/C polymorphism of the 5-HT2A receptor gene and schizophrenia in Chinese population.
|
9264136 |
1997 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings are consistent with other recent association studies which argue against the involvement of the 5-HT2a/T102C polymorphism in predisposition to schizophrenia.
|
9259371 |
1997 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings indicate that the T102C polymorphisms of the 5-HT2A receptor gene does not play a substantial role in schizophrenia nor help evaluate susceptibility to schizophrenia.
|
12606842 |
2003 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that PPI and habituation are modulated by 5-HT(2A)R A-1438G and T102C genotype in schizophrenia.
|
18420180 |
2008 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the HTR2A T102C polymorphism may confer susceptibility to schizophrenia in Han Chinese.
|
23857788 |
2013 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies have also shown an association between the allele C of 102T/C polymorphism in the 5-HT2A receptor gene and schizophrenia.
|
10686553 |
2000 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies suggest that the 5-hydroxytryptamine receptor 2A (5-HT2A) gene (HTR2A) T102C and G-1438A polymorphisms may influence treatment response of risperidone or olanzapine for schizophrenia's negative symptoms (e.g., blunted affect and social withdrawal).
|
15882132 |
2005 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a 5-HT2A receptor gene T102C polymorphism has been reported to be associated with clinical response to 5-HT2A receptor antagonist in patients with schizophrenia, suggesting this polymorphism of the gene affects the 5-HT2A receptor function.
|
10781645 |
2000 |
|
rs6313
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the study was to investigate whether the 5-HT2A receptor gene's polymorphisms (His452Tyr and T102C) have an influence on the response to olanzapine in patients with schizophrenia.
|
21912188 |
2011 |