|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
|
21460840 |
2011 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci.
|
21460840 |
2011 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
|
21460840 |
2011 |
|
rs3752246
|
|
Alzheimer's Disease
|
G |
0.850 |
GeneticVariation
|
GWASDB |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
|
rs3752246
|
|
Alzheimer's Disease
|
G |
0.850 |
GeneticVariation
|
GWASCAT |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
|
rs3752246
|
|
Alzheimer's Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
The novel ABCA7 SNP, rs3752246, tended to be associated with AD in our study.
|
23556446 |
2013 |
|
rs115550680
|
|
Alzheimer's Disease
|
G |
0.830 |
GeneticVariation
|
GWASCAT |
Genome-wide significance in fully adjusted models (sex, age, APOE genotype, population stratification) was observed for a SNP in ABCA7 (rs115550680, allele = G; frequency, 0.09 cases and 0.06 controls; odds ratio [OR], 1.79 [95% CI, 1.47-2.12]; P = 2.2 × 10(-9)), which is in linkage disequilibrium with SNPs previously associated with Alzheimer disease in Europeans (0.8 < D' < 0.9).
|
23571587 |
2013 |
|
rs115550680
|
|
Alzheimer's Disease
|
G |
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide significance in fully adjusted models (sex, age, APOE genotype, population stratification) was observed for a SNP in ABCA7 (rs115550680, allele = G; frequency, 0.09 cases and 0.06 controls; odds ratio [OR], 1.79 [95% CI, 1.47-2.12]; P = 2.2 × 10(-9)), which is in linkage disequilibrium with SNPs previously associated with Alzheimer disease in Europeans (0.8 < D' < 0.9).
|
23571587 |
2013 |
|
rs115550680
|
|
Alzheimer's Disease
|
|
0.830 |
GeneticVariation
|
BEFREE |
Genome-wide significance in fully adjusted models (sex, age, APOE genotype, population stratification) was observed for a SNP in ABCA7 (rs115550680, allele = G; frequency, 0.09 cases and 0.06 controls; odds ratio [OR], 1.79 [95% CI, 1.47-2.12]; P = 2.2 × 10(-9)), which is in linkage disequilibrium with SNPs previously associated with Alzheimer disease in Europeans (0.8 < D' < 0.9).
|
23571587 |
2013 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Besides the previously reported APOE and CR1 loci, we found that the ABCA7 (rs3764650; P = .02) and CD2AP (rs9349407; P = .03) AD susceptibility loci are associated with neuritic plaque burden.
|
23836404 |
2013 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, a large genome-wide association study has revealed that polymorphism of alleles and genotypes in rs3,764,650 within ABCA7 gene is associated with Alzheimer disease in whites.
|
24113560 |
2015 |
|
rs4147929
|
|
Alzheimer's Disease
|
A |
0.860 |
GeneticVariation
|
GWASCAT |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
|
24162737 |
2013 |
|
rs4147929
|
|
Alzheimer's Disease
|
A |
0.860 |
GeneticVariation
|
GWASDB |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
|
24162737 |
2013 |
|
rs3752232
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
There were four significant associations between genotypes and phenotypes of AD patients: CR1 SNP rs11803956 correlated with Mini-Mental State Examination (MMSE) score (β=1.718, Pcorrected=0.002); ABCA7 SNP rs3752232 correlated with Rey Complex Figure Test (RCFT) copy score (β=-6.861, Pcorrected=0.013); APOE SNP rs2075650 correlated with the percentile of RCFT copy score (β=14.005, Pcorrected=0.021) and the percentile of total score in phonemic fluency (β=11.052, Pcorrected=0.035).
|
24530172 |
2014 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We observed a significant association between rs3764650 and AD using the allele (P = 1.76E - 26, odds ratio (OR) = 1.21, 95 % confidence interval (CI) 1.17-1.26), dominant (P = 4.00E - 04, OR = 1.17, 95 % CI 1.07-1.28), recessive (P = 3.00E - 03, OR = 1.43, 95 % CI 1.13-1.81), and additive models (P = 3.00E - 03, OR = 1.49, 95 % CI 1.16-1.91).
|
24643655 |
2014 |
|
rs4147929
|
|
Alzheimer's Disease
|
|
0.860 |
GeneticVariation
|
BEFREE |
Large-scale genome-wide association studies (GWAS) have revealed that the ABCA7 rs3764650 polymorphism (or its proxies, namely rs115550680, rs3752246, and rs4147929) is associated with Alzheimer's disease (AD) susceptibility in individuals of Caucasian ancestry.
|
24643655 |
2014 |
|
rs3752246
|
|
Alzheimer's Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
Large-scale genome-wide association studies (GWAS) have revealed that the ABCA7 rs3764650 polymorphism (or its proxies, namely rs115550680, rs3752246, and rs4147929) is associated with Alzheimer's disease (AD) susceptibility in individuals of Caucasian ancestry.
|
24643655 |
2014 |
|
rs115550680
|
|
Alzheimer's Disease
|
|
0.830 |
GeneticVariation
|
BEFREE |
Large-scale genome-wide association studies (GWAS) have revealed that the ABCA7 rs3764650 polymorphism (or its proxies, namely rs115550680, rs3752246, and rs4147929) is associated with Alzheimer's disease (AD) susceptibility in individuals of Caucasian ancestry.
|
24643655 |
2014 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
After adjustment of age, sex, and APOE ε4 allele, rs3764650 remained to be an independent predictor of AD (p = 0.001).
|
24908168 |
2014 |
|
rs148078867
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In total, we identified 78 potentially damaging rare variants (frequency <1%), including ABCA7 p.L400V in a family with Alzheimer's disease and LRRK2 p.R1514Q in 6 of 98 patients with Parkinson's disease (6.1%).
|
25174650 |
2015 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
An intronic low-frequency variant rs78117248 (minor allele frequency 3·8% in 58 patients with Alzheimer's disease and in controls 1·8% in 28 controls) showed strongest association with Alzheimer's disease (odds ratio 2·07, 95% CI 1·31-3·27; p=0·0016), and remained significant after conditioning for the GWAS top single nucleotide polymorphisms rs3764650, rs4147929, and rs3752246 (2·00, 1·22-3·26; p=0·006).
|
26141617 |
2015 |
|
rs4147929
|
|
Alzheimer's Disease
|
|
0.860 |
GeneticVariation
|
BEFREE |
An intronic low-frequency variant rs78117248 (minor allele frequency 3·8% in 58 patients with Alzheimer's disease and in controls 1·8% in 28 controls) showed strongest association with Alzheimer's disease (odds ratio 2·07, 95% CI 1·31-3·27; p=0·0016), and remained significant after conditioning for the GWAS top single nucleotide polymorphisms rs3764650, rs4147929, and rs3752246 (2·00, 1·22-3·26; p=0·006).
|
26141617 |
2015 |
|
rs3752246
|
|
Alzheimer's Disease
|
|
0.850 |
GeneticVariation
|
BEFREE |
An intronic low-frequency variant rs78117248 (minor allele frequency 3·8% in 58 patients with Alzheimer's disease and in controls 1·8% in 28 controls) showed strongest association with Alzheimer's disease (odds ratio 2·07, 95% CI 1·31-3·27; p=0·0016), and remained significant after conditioning for the GWAS top single nucleotide polymorphisms rs3764650, rs4147929, and rs3752246 (2·00, 1·22-3·26; p=0·006).
|
26141617 |
2015 |
|
rs78117248
|
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
An intronic low-frequency variant rs78117248 (minor allele frequency 3·8% in 58 patients with Alzheimer's disease and in controls 1·8% in 28 controls) showed strongest association with Alzheimer's disease (odds ratio 2·07, 95% CI 1·31-3·27; p=0·0016), and remained significant after conditioning for the GWAS top single nucleotide polymorphisms rs3764650, rs4147929, and rs3752246 (2·00, 1·22-3·26; p=0·006).
|
26141617 |
2015 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A comprehensive literature search for studies involving the association between gene polymorphisms and AD was performed, and we finally selected 3 genes (4 polymorphisms) for the meta-analysis: ABCA7 (rs3764650), CD33 (rs3865444), and TOMM40 (rs157580, rs2075650).
|
26795201 |
2016 |