|
rs1040411
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recent GWAS study identified rs4946728 and rs1040411 noncoding SNPs located between PRDM1 and ATG1 genes on chromosome 6q21 as risk factors for secondary malignancies in patients formerly treated with radiotherapy for pediatric Hodgkin disease.
|
24306881 |
2014 |
|
rs10420252
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two SNPs in COX6B1 (complex IV) were associated with lymph node metastasis in a dominant model (rs6510502, OR = 1.75, 95% CI 1.20-2.57; rs10420252, OR = 1.68, 95% CI 1.11-2.53); rs6510502 was associated also with distant metastasis (OR = 1.67, 95% CI 1.09-2.56 in a dominant model).
|
22545919 |
2012 |
|
rs1047781
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs1047781 (chr19- FUT2) (A/T) was associated with elevated sCEA levels, and rs8176746 (chr9- ABO) was associated with the regional lymph metastasis in the CRC patients.
|
24941225 |
2014 |
|
rs104894228
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The HRAS c.37G>C mutation was also found in 8 of 8 associated secondary tumors.
|
22683711 |
2012 |
|
rs1049074086
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
S100P has been shown to mediate tumor growth, metastasis and invasion through the binding of Ca(2+) ions, receptor for advanced glycation end products, cytoskeletal protein ezrin, calcyclin-binding protein/Siah-1-interacting protein and cathepsin D. S100P could potentially serve as diagnostic marker, prognostic/predictive indicator and therapy target for different carcinomas.
|
21947242 |
2012 |
|
rs10491121
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, compared with AA carriers, those carrying the AG + GG genotype at SNP rs10491121 were at lower risk of developing distant metastasis, while the presence of the AT genotype at SNP rs1719153 increased the likelihood of pathologic grade (G3 or G4) disease.
|
30123055 |
2018 |
|
rs1051660
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We detected significant association of the rs1051660 adjusted on metastasis and pain (<i>P</i>=0.02), no other association has been detected between the 7 polymorphisms screened and the dose of morphine needed for pain relief.
|
29259946 |
2017 |
|
rs1052667
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, rs1052667 polymorphism was correlated with such pathological features of osteosarcoma as tumor size, tumor grade, and tumor metastasis.
|
25136583 |
2014 |
|
rs1053129
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Also patients homozygous for the G allele of rs1053129 in the dihydrofolate reductase (DHFR) gene were more likely to have a metastasis (45%, P= 0.005), and the methylenetetetrahydrofolate reductase (MTHFR) 677C allele was associated with higher degree of liver toxicity (88%, P=0.007).
|
25778468 |
2015 |
|
rs1056123575
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
From this analysis, we show that the Cav-1(P132L) expression signature contains numerous genes that have been previously associated with cell migration, invasion, and metastasis.
|
19395651 |
2009 |
|
rs1056629
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the rs1056629 polymorphism interfered with the interaction between MMP9 mRNA and miR-491 and is associated with the metastasis of OS cells.
|
27023472 |
2016 |
|
rs1057519695
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The primary tumor and all the available metastases exhibited the same molecular oncogenic markers (namely, the RAS mutation p.Q61R and the telomerase promoter mutation C228T).
|
28781658 |
2017 |
|
rs1057519710
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Sequence analysis revealed K642E and D820Y mutations in two metastases.
|
19035443 |
2009 |
|
rs1057519783
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In another case, EML4-ALK fusion detected in the primary tumor was associated with ALK G1202R secondary resistance mutation in the post-treatment metastasis.
|
30946933 |
2019 |
|
rs1057519816
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Another patient with the S310F mutation had an apocrine carcinoma with seven lymph nodes positive for metastasis, classified as HER2 3+ by the HercepTest, but which was FISH-negative, as well as ER-negative and PgR-negative.
|
26642960 |
2016 |
|
rs1057519834
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The primary tumor and all the available metastases exhibited the same molecular oncogenic markers (namely, the RAS mutation p.Q61R and the telomerase promoter mutation C228T).
|
28781658 |
2017 |
|
rs1057519864
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The consequence of suppressing AR-F876L may then abrogate AR-F876L mediated CRPC cell proliferation and metastasis.
|
27233475 |
2016 |
|
rs1057519874
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we describe how the hyperactivation of Rac1 via the P29S mutation (Rac1<sup>P29S</sup>) in melanoma hijacks branched actin network assembly to coordinate proliferative cues that facilitate metastasis and drug resistance.
|
31063759 |
2019 |
|
rs1057519902
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We report the case of a 17-year-old female with an H3F3A G34R mutated infiltrative glioma who developed painful osseous metastases to her pelvis and spine within 3 months of clinical presentation.
|
31139567 |
2019 |
|
rs1057519903
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found conservation of heterozygous K27M mutations in H3F3A (n = 4) or HIST1H3B (n = 3) across all primary, contiguous, and metastatic tumor sites in all DIPGs.
|
26727948 |
2016 |
|
rs1057519904
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found conservation of heterozygous K27M mutations in H3F3A (n = 4) or HIST1H3B (n = 3) across all primary, contiguous, and metastatic tumor sites in all DIPGs.
|
26727948 |
2016 |
|
rs1057519975
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The objective of the study was to check whether a polymorphism in the RAD51 gene (135 G>C), Ku70 protein expression, and tumor microenvironment: proliferation rate measured by BrdUrdLI and Ki-67LI, hypoxia (glucose transporter-1 expression), P53 protein expression, and DNA ploidy can influence DNA repair capacity, the factors contributing to patient overall survival (OS) and the incidence of recurrences and metastases.
|
30289394 |
2019 |
|
rs1063192
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
On the other hand, patients with the polymorphic CDKN2B gene (rs1063192) presented distant metastases (36.3%; P=0.0261).
|
25565272 |
2014 |
|
rs10814325
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
RECK gene rs10814325 T>C could not be considered a risk factor for HCC development on top of HCV, but may be related to the disease progression and metastasis.
|
27268601 |
2016 |
|
rs10817938
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
OSCC patients with C allele at rs10817938 were more susceptible to lymph metastases, poor pathological differentiation and late TNM stage (OR = 1.67, 95% CI 1.17-2.37; OR = 1.64, 95% CI 1.18-2.28; OR = 1.54, 95% CI 1.11-2.14; respectively).
|
27622501 |
2016 |