|
rs4680
|
|
Psychotic Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relationship of performance errors with catechol-O-methyltransferase (COMT) rs4680 (Val158Met) genotype (Met carriers vs. Val homozygotes) on test performance before and after antipsychotic treatment in 32 first episode psychosis (FEP) patients was examined.
|
29941295 |
2018 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong association with neuroplasticity effect in schizophrenia.
|
29559020 |
2018 |
|
rs4680
|
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Logistic regressions with interaction terms (adjusted for sex and age) revealed that rs4680 interacted with total childhood adversity, emotional abuse and physical abuse in predicting panic disorder: Respective childhood adversities predicted panic disorder in carriers of the Val/Met or Met/Met genotype, but not Val/Val genotype.
|
29574383 |
2018 |
|
rs4680
|
|
Psychotic Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta - analysis.
|
29444152 |
2018 |
|
rs4680
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotype was carried out for 5 single nucleotide polymorphisms (rs4646903, rs1056836, rs1695, rs4970737, and rs4680) using direct sequencing.The polymorphic genotypes of glutathione S-transferase (GSTP1) (P = .044) and catechol-O-methyltransferase (COMT) (P = .008) showed significantly different distributions, while that of cytochrome P450 (CYP1B1) (P = .051) showed a slight difference in distribution between healthy women and patients with breast cancer.
|
30461653 |
2018 |
|
rs4680
|
|
Cannabis use
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis was performed using papers investigating the interaction between cannabis use and catechol-O-methyl transferase (COMT) polymorphism Val158Met (COMTVal158Met).
|
29444152 |
2018 |
|
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta - analysis.
|
29444152 |
2018 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The <i>COMT</i> Val 108/158 Met polymorphism (rs4680) may affect treatment response to antipsychotics, as well as metabolism and dynamics of neurotransmitters during the treatment of schizophrenia.
|
29950847 |
2018 |
|
rs4680
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotype was carried out for 5 single nucleotide polymorphisms (rs4646903, rs1056836, rs1695, rs4970737, and rs4680) using direct sequencing.The polymorphic genotypes of glutathione S-transferase (GSTP1) (P = .044) and catechol-O-methyltransferase (COMT) (P = .008) showed significantly different distributions, while that of cytochrome P450 (CYP1B1) (P = .051) showed a slight difference in distribution between healthy women and patients with breast cancer.
|
30461653 |
2018 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results imply that PPI might be modulated by four genotypes - COMT rs4680 (primarily in males), GRIK3 rs1027599, TCF4 rs9960767, and PRODH rs385440 - indicating a role of these gene variations in the development of early information processing deficits in schizophrenia.
|
29287625 |
2018 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Such associations of <i>COMT</i> rs4680 and rs4818 high-activity (G variants), as well as G-G/G-G haplotype, with the lower risk of TRS in females, but not in males, suggest significant, but sex-specific influence of <i>COMT</i> variants on the development of treatment-resistance in patients with schizophrenia.
|
30018555 |
2018 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Cox proportional regression analysis adjusted for covariates revealed that among patients with PD, those carrying the high-COMT activity haplotype (G_C_C_G for rs6269, rs4633, rs4818, and rs4680) showed a high risk of cognitive decline (hazard ratio = 3.24; P = 0.02).
|
29439855 |
2018 |
|
rs4680
|
|
Major Depressive Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We measured COMT gene methylation and polymorphisms (Val158Met) at the rs4468 locus in peripheral blood samples of healthy controls (n = 90) and patients with MDD (n = 90).
|
29723539 |
2018 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine whether dopaminergic (rs1076560 DRD2 G > T and rs4680 catechole-o-methyltranspherase (COMT) Val158Met) or brain derived neurotrophic factor (rs6265 BDNF Val66Met) genetic polymorphisms are associated with gait function and medication responsiveness in Parkinson's disease.
|
29249680 |
2018 |
|
rs4680
|
|
Abnormal behavior
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between COMT Val158Met and psychiatric disorders: A comprehensive meta-analysis.
|
28608575 |
2018 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, the methylation level of an rs4680-related CpG site was significantly associated with the Val/Val genotype which may contribute to the homicidal behavior of schizophrenia patients.
|
29455339 |
2018 |
|
rs4680
|
|
Nonorganic psychosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relationship of performance errors with catechol-O-methyltransferase (COMT) rs4680 (Val158Met) genotype (Met carriers vs. Val homozygotes) on test performance before and after antipsychotic treatment in 32 first episode psychosis (FEP) patients was examined.
|
29941295 |
2018 |
|
rs4680
|
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between COMT Val158Met and psychiatric disorders: A comprehensive meta-analysis.
|
28608575 |
2018 |
|
rs4680
|
|
Psychotic Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val158Met) appears to influence cognition in people with alcohol/substance use disorders (AUD/SUD) and in those with psychosis.
|
28635556 |
2017 |
|
rs4680
|
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Sixty-four outpatients with BD in full or partial remission were stratified according to COMT Val158Met genotype (ValVal [n=13], ValMet [n=34], and MetMet [n=17]).
|
28544426 |
2017 |
|
rs4680
|
|
Depressive disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We concluded that depression and COMT rs4680 "GG" and "GA" genotypes and COMT rs6267 "GT" genotype contribute to pain in PD patients.
|
28740224 |
2017 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T and COMT Val158Met interact with CA to increase risk of schizophrenia.
|
28556887 |
2017 |
|
rs4680
|
|
Psychotic Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relationship between age at psychosis onset and COMT Val158Met and BDNF Val66Met polymorphisms with early cannabis use as well as those factors associated with early cannabis use were investigated.
|
28142064 |
2017 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Executive control in schizophrenia: a preliminary study on the moderating role of COMT Val158Met for comorbid alcohol and substance use disorders.
|
28635556 |
2017 |
|
rs4680
|
|
Anxiety
|
|
0.100 |
GeneticVariation
|
BEFREE |
Analyses suggest that COMT val158met moderates the influence of early life stress on preschool-age symptoms of anxiety.
|
28859863 |
2017 |