|
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The Asp299Gly and Thr399Ile variants do not show an association with CD, UC, or IBD as a group, indicating that these polymorphisms are likely not the causal ones.
|
15905704 |
2005 |
|
rs4986790
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp, Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.
|
15655821 |
2005 |
|
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
In a geographic area in Southern Italy with high incidence of CD we investigated IP (lactulose/mannitol testing) together with the three main mutations of the NOD2/CARD15 and the D299G polymorphism of the toll-like receptor (TLR)-4 gene in 23 families of CD patients (patients and first-degree relatives).
|
16393227 |
2005 |
|
rs4986790
|
|
Crohn Disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
We have reported on a novel association of the TLR4 Asp299Gly polymorphism with both CD and UC.
|
15194649 |
2004 |
|
rs4986790
|
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation
|
BEFREE |
We have reported on a novel association of the TLR4 Asp299Gly polymorphism with both CD and UC.
|
15194649 |
2004 |
|
rs4986790
|
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the clinical characteristics and frequency of TLR4 polymorphisms (Asp299Gly and Thr 399Ile) in a cohort of Brazilian patients with AS.
|
27692393 |
2018 |
|
rs4986790
|
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
The present study might suggest that TLR4 D299G/T399I polymorphisms are not associated with RA/AS susceptibility.
|
22717291 |
2012 |
|
rs4986790
|
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
The minor allele frequency for the Asp299Gly variant (G) was significantly higher in AS cases compared to controls (7.5% vs 2.6%, respectively; OR 3.10, p = 0.037).
|
17143969 |
2007 |
|
rs4986790
|
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms do not contribute to disease susceptibility in either AS or ReA.
|
16567359 |
2006 |
|
rs4986790
|
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
No significant difference between the frequencies of the Asp299Gly genotype or the Thr399Ile genotype between patients with AS and healthy HLA-B27 controls was found.
|
16837493 |
2006 |
|
rs4986790
|
|
Ankylosing spondylitis
|
|
0.760 |
GeneticVariation
|
BEFREE |
There is no evidence for involvement of the CD14 C-260T or TLR4 A896G polymorphisms in susceptibility to AS.
|
15647432 |
2005 |
|
rs4986790
|
|
Psoriasis
|
|
0.710 |
GeneticVariation
|
BEFREE |
Significant association was observed between a missense variant rs4986790 of TLR4 (Asp229Gly) and plaque type psoriasis (p = 2 × 10(-4)) which was also notable in those with psoriatic arthritis (p = 2 × 10(-4)) and early-onset psoriasis (p = 8 × 10(-4)).
|
26830904 |
2016 |
|
rs4986790
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
|
rs4986790
|
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, the TLR4 rs4986790 polymorphism was significantly correlated with the risk of IBD in West Asians, while the TLR9 rs352140 polymorphism was significantly associated with the risk of IBD in Africans.
|
30617966 |
2019 |
|
rs4986790
|
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
|
rs4986790
|
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TLR4-Thr399Ile variant was strongly associated with susceptibility to IBD, whereas TLR4-Asp299Gly seems to play a role in the clinical expression of UC.
|
29055077 |
2017 |
|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
There were no associations of TLR4 rs11536878 and rs4986790 SNPs with RA disease activity progression.
|
25573402 |
2015 |
|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our overall analyses indicated that TLR4 Asp299Gly polymorphism might contribute to RA pathogenesis.
|
25499175 |
2015 |
|
rs4986790
|
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, a statistically significant association between TLR4 Asp299Gly polymorphism and IBD was observed among high quality studies evaluating Caucasians, but not Asians.
|
26023918 |
2015 |
|
rs4986790
|
|
Inflammatory Bowel Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, meta-analysis demonstrated significantly higher frequencies of both Asp299Gly and Thr399Ile SNPs in IBD and CD and for 399Ileu carriage in UC patients.
|
25492126 |
2014 |
|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis shows lack of an association between the TLR4 Asp299Gly polymorphism and RA.
|
23325096 |
2014 |
|
rs4986790
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Asp299Gly and Thr399Ile polymorphisms in TLR4 have been associated with a variety of inflammatory and infectious conditions including gastric cancer.
|
24295404 |
2014 |
|
rs4986790
|
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Asp299Gly and Thr399Ile polymorphisms in TLR4 have been associated with a variety of inflammatory and infectious conditions including gastric cancer.
|
24295404 |
2014 |
|
rs4986790
|
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, we detected that A allele carriers of the TLR4 Asp299Gly polymorphism might have an increase risk of gastric cancer in the Helicobacter pylori-positive population (G allele vs. A allele: OR=2.01, 95%CI: 1.22, 3.31).
|
24007538 |
2013 |
|
rs4986790
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis of three European studies showed no significant association between the TLR4 Asp299Gly (rs4986790) polymorphism and rheumatoid arthritis (odds ratio = 0.897, 95% confidence interval = 0.734-1.096, P = 0.289).
|
23420357 |
2013 |