Source: CLINVAR

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs104894228
rs104894228
HRAS ; LRRC56
CUI: C0027651
Disease: Neoplasms
Neoplasms 		A 0.710 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs104894228
rs104894228
HRAS ; LRRC56
CUI: C0027651
Disease: Neoplasms
Neoplasms 		T 0.710 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs1057519816
rs1057519816
ERBB2
CUI: C0027651
Disease: Neoplasms
Neoplasms 		A 0.710 GeneticVariation CLINVAR Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. 22908275

2012
dbSNP: rs1057519816
rs1057519816
ERBB2
CUI: C0027651
Disease: Neoplasms
Neoplasms 		T 0.710 GeneticVariation CLINVAR Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. 22908275

2012
dbSNP: rs1057519824
rs1057519824
MET
CUI: C0027651
Disease: Neoplasms
Neoplasms 		G 0.710 GeneticVariation CLINVAR An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. 17483355

2007
dbSNP: rs1057519837
rs1057519837
CTNNB1
CUI: C0027651
Disease: Neoplasms
Neoplasms 		G 0.710 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs1057519855
rs1057519855
HRAS ; LRRC56
CUI: C0027651
Disease: Neoplasms
Neoplasms 		AC 0.710 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs1057519855
rs1057519855
HRAS ; LRRC56
CUI: C0027651
Disease: Neoplasms
Neoplasms 		TC 0.710 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs121913246
rs121913246
MET
CUI: C0027651
Disease: Neoplasms
Neoplasms 		G 0.710 GeneticVariation CLINVAR An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. 17483355

2007
dbSNP: rs121913343
rs121913343
TP53
CUI: C0027651
Disease: Neoplasms
Neoplasms 		A 0.710 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs121913496
rs121913496
HRAS ; LRRC56
CUI: C0027651
Disease: Neoplasms
Neoplasms 		G 0.710 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs121913496
rs121913496
HRAS ; LRRC56
CUI: C0027651
Disease: Neoplasms
Neoplasms 		A 0.710 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs28933369
rs28933369
ERBB2 ; MIR4728
CUI: C0027651
Disease: Neoplasms
Neoplasms 		A 0.710 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs1057519730
rs1057519730
MAP2K1
CUI: C0027651
Disease: Neoplasms
Neoplasms 		A 0.700 GeneticVariation CLINVAR MEK1 mutations confer resistance to MEK and B-RAF inhibition. 19915144

2009
dbSNP: rs1057519757
rs1057519757
PIK3R1
CUI: C0027651
Disease: Neoplasms
Neoplasms 		A 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs1057519757
rs1057519757
PIK3R1
CUI: C0027651
Disease: Neoplasms
Neoplasms 		C 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs1057519757
rs1057519757
PIK3R1
CUI: C0027651
Disease: Neoplasms
Neoplasms 		C 0.700 GeneticVariation CLINVAR Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design. 19962457

2010
dbSNP: rs1057519757
rs1057519757
PIK3R1
CUI: C0027651
Disease: Neoplasms
Neoplasms 		A 0.700 GeneticVariation CLINVAR Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design. 19962457

2010
dbSNP: rs1057519817
rs1057519817
ERBB3
CUI: C0027651
Disease: Neoplasms
Neoplasms 		A 0.700 GeneticVariation CLINVAR Oncogenic ERBB3 mutations in human cancers. 23680147

2013
dbSNP: rs1057519819
rs1057519819
MAP2K1
CUI: C0027651
Disease: Neoplasms
Neoplasms 		C 0.700 GeneticVariation CLINVAR MEK1 mutations confer resistance to MEK and B-RAF inhibition. 19915144

2009
dbSNP: rs1057519820
rs1057519820
MAP2K1
CUI: C0027651
Disease: Neoplasms
Neoplasms 		C 0.700 GeneticVariation CLINVAR MEK1 mutations confer resistance to MEK and B-RAF inhibition. 19915144

2009
dbSNP: rs1057519821
rs1057519821
MAP2K1
CUI: C0027651
Disease: Neoplasms
Neoplasms 		T 0.700 GeneticVariation CLINVAR MEK1 mutations confer resistance to MEK and B-RAF inhibition. 19915144

2009
dbSNP: rs1057519821
rs1057519821
MAP2K1
CUI: C0027651
Disease: Neoplasms
Neoplasms 		C 0.700 GeneticVariation CLINVAR MEK1 mutations confer resistance to MEK and B-RAF inhibition. 19915144

2009
dbSNP: rs1057519822
rs1057519822
MAP2K1
CUI: C0027651
Disease: Neoplasms
Neoplasms 		A 0.700 GeneticVariation CLINVAR MEK1 mutations confer resistance to MEK and B-RAF inhibition. 19915144

2009
dbSNP: rs1057519823
rs1057519823
MAP2K1
CUI: C0027651
Disease: Neoplasms
Neoplasms 		C 0.700 GeneticVariation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898

2013