|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis.
|
22937072 |
2012 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
RNA was extracted from positively selected CD56+, CD8+, and CD4+ mononuclear cells and the 'residual' cells from 12 RA patients heterozygous for the PTPN22 C1858T single nucleotide polymorphism (SNP) (rs2476601).
|
22632125 |
2012 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population.
|
22704547 |
2012 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Our data depict a model that can reconcile the conflicting observations on the functional impact of the C1858T SNP and also suggest that PTPN22.6 is a novel biomarker of rheumatoid arthritis.
|
22427951 |
2012 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
This association is independent of the well-established association between PTPN22 R620W and RA.
|
21279993 |
2011 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
To investigate genotype-phenotype correlation and gene-environment interaction between PTPN22 R620W environmental factors such as tobacco/hormonal treatments in an inception cohort of RA patients.
|
21752868 |
2011 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
The SNP rs2476601 located in the PTPN22 gene is the sole common genetic variant associated with RA in the 1p13.2 region, suggesting that neighbor genes of PTPN22 do not have a major influence in RA.
|
21965649 |
2011 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis.
|
21949702 |
2011 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
We found that PTPN22 1858C/T polymorphism could increase RA risk in overall genetic models in Europeans (T-allele vs. C-allele, OR = 1.54, 95% CI = 1.47-1.62, P(heterogeneity) = 0.143; TT vs. CC, OR = 2.86, 95% CI = 2.29-3.57, P(heterogeneity) = 0.302; TC vs. CC, OR = 1.45, 95% CI = 1.38-1.53, P(heterogeneity) = 0.273; TT + TC vs. CC, OR = 1.49, 95% CI = 1.42-1.56, P(heterogeneity) = 0.208; TT vs. TC + CC, OR = 2.52, 95% CI = 1.95-3.25, P(heterogeneity) = 0.296).
|
22209972 |
2011 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Recently a single-nucleotide polymorphism (SNP) 1858 C/T within this gene was shown to be a risk factor for several autoimmune diseases, such as rheumatoid arthritis (RA), Graves' Disease (GD), systemic lupus erythematosus (SLE), Wegener's granulomatosis (WG) and type 1 diabetes mellitus (T1D).
|
21467606 |
2011 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
The aim of this study was to assess whether the C1858T polymorphism of PTPN22 also confers increased risk for SLE and RA in the genetically homogeneous population of Crete.
|
21543514 |
2011 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Our study suggests that the PTPN22 C1858T polymorphism acts as a susceptibility gene for autoantibody-positive RA in Turkey.
|
21506938 |
2011 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
We genotyped SNPs rs3761847 and rs7021206 at the TRAF1/C5 locus and rs2476601 SNP in the PTPN22 gene in a Han Chinese cohort composed of 576 patients with RA and 689 controls.
|
21492465 |
2011 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
We have no evidence for a common variant additional to rs2476601 within the PTPN22 locus that influences the risk of RA.
|
20975833 |
2010 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-analysis.
|
20498205 |
2010 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
PTPN22 1858C>T polymorphism is strongly associated with rheumatoid arthritis but not with a response to methotrexate therapy.
|
20888443 |
2010 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Protein tyrosine phosphatase gene C1858T allele confers risk for rheumatoid arthritis in Hungarian subjects.
|
19034456 |
2009 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
However, we were able to replicate the association signals between RA and HLA-DRB1 alleles, STAT4 (rs7574865), PTPN22 (rs2476601) and OLIG3/TNFAIP3 (rs10499194 and rs6920220).
|
19445664 |
2009 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
Our data suggest that the PTPN22 C1858T single nucleotide polymorphism has no or minor effect on RA and AITDs susceptibility in the Tunisian population.
|
19343596 |
2009 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
167 patients with RA and 177 healthy controls are genotyped by polymerase chain reaction (PCR)-RFLP for the SNP (rs2476601, A/G) of PTPN22 gene.
|
19357851 |
2009 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
The disease association of the common 1858C>T Arg620Trp (rs2476601) nonsynonymous single nucleotide polymorphism (SNP) of protein tyrosine phosphatase; nonreceptor type 22 (PTPN22) on chromosome 1p13 has been confirmed in type 1 diabetes and also in other autoimmune diseases, including rheumatoid arthritis and Graves' disease.
|
18305142 |
2008 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
We studied RA risk associated with PTPN22 (rs2476601), PADI-4 (rs2240340), and CTLA-4 (rs3087243) in the Nurses' Health Study (NHS) and NHSII.
|
18462498 |
2008 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
The functional (R620W) variant of human PTPN22 (protein tyrosine phosphatase non-receptor 22) gene has been implicated in the risk to several autoimmune disorders, including type 1 diabetes, Graves' disease, rheumatoid arthritis and systemic lupus erythematosus.
|
18194365 |
2008 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
To analyse the relationship between the presence of auto-antibodies [rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP)], HLA-DRB1 alleles and PTPN22 1858 C/T polymorphism and test the value of their combination as susceptibility markers for rheumatoid arthritis (RA).
|
18156150 |
2008 |
|
rs2476601
|
|
Rheumatoid Arthritis
|
|
1.000 |
GeneticVariation
|
BEFREE |
We investigated whether polymorphism 1858C>T in PTPN22 gene is associated with susceptibility to allergic asthma and RA in a Polish population.
|
17579671 |
2007 |