|
rs786205155
|
|
Acute lymphocytic leukemia
|
|
0.710 |
GeneticVariation
|
BEFREE |
Here we identify a novel germline ETV6 p. L349P mutation in a kindred affected by thrombocytopenia and ALL.
|
26102509 |
2015 |
|
rs786205155
|
|
Acute lymphocytic leukemia
|
C |
0.710 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs121909646
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs121913488
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs587776834
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs587782545
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs63750250
|
|
Acute lymphocytic leukemia
|
AT |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs730881864
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs752746786
|
|
Acute lymphocytic leukemia
|
T |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs767215758
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs767454740
|
|
Acute lymphocytic leukemia
|
G |
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs786205154
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs869312821
|
|
Acute lymphocytic leukemia
|
C |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that C677T polymorphism of MTHFR seems to be a good marker for MTX-related toxicity in ALL.
|
30545275 |
2019 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association Between the 5,10-MTHFR 677C>T and RFC1 80G>A Polymorphisms and Acute Lymphoblastic Leukemia.
|
31499477 |
2019 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p<0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p<0.05) in developing ALL for all genetic models.
|
31188929 |
2019 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Use of MTHFR C677T polymorphism and plasma pharmacokinetics to predict methotrexate toxicity in patients with acute lymphoblastic leukemia.
|
29911750 |
2018 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association was detected significantly between MTHFR C677T polymorphism and ALL reducing susceptibility.
|
28062297 |
2017 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
There were no associations between MTHFR C677T or MTHFR A1298C polymorphisms and ALL susceptibility.
|
28646637 |
2017 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T and A1298C genotypes were analyzed using allele discrimination tests with Taq-Man fluorescent probes.The MTHFR 677TT genotype was related to a 2-fold increase in risk of ALL (P = .014).
|
29390492 |
2017 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a case-control study of 203 patients with ALL and 246 controls and meta-analysis in the Indian population, we showed an insignificant association of MTHFR C677T and A1298C genotypes with childhood and adult ALL.
|
25115513 |
2015 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aims of this study were to (a) to determine the prevalence of seven common genetic polymorphisms including those that affect the folate and/or thiopurine metabolic pathways, i.e. cyclin D1 (CCND1-G870A), γ-glutamyl hydrolase (GGH-C452T), methylenetetrahydrofolate reductase (MTHFR-C677T and MTHFR-A1298C), thymidylate synthase promoter (TYMS-TSER), thiopurine methyltransferase (TPMT*3A and TPMT*3C) and inosine triphosphate pyrophosphatase (ITPA-C94A), in Caucasian (n = 94, age < 20) and Vietnamese (n = 141, age < 16 years) childhood ALL and (b) to assess the impact of a multilocus genetic risk score (MGRS) on relapse-free survival (RFS) using a Cox proportional-hazards regression model.
|
25099492 |
2015 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant differences were found between patients with ALL and controls for the frequency of MTHFR C677T and A1298C alleles, genotypes, combined genotypes or haplotypes.
|
25629981 |
2015 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate the influence of C677T and A1298C polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene on MTX-induced toxicity during treatment of children with ALL.
|
26528799 |
2015 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results indicated that the MTHFR C677T T allele was a protective biomarker for childhood ALL in Taiwan, and the association was more significant in male patients and in patients 3.5 years of age or older at onset of disease.
|
25793509 |
2015 |