|
rs11141915
|
|
Pancreatic carcinoma
|
T |
0.800 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
|
22293537 |
2012 |
|
rs11141915
|
|
Pancreatic carcinoma
|
T |
0.800 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
|
22293537 |
2012 |
|
rs121912578
|
|
Pancreatic carcinoma
|
|
0.800 |
GeneticVariation
|
UNIPROT |
|
|
|
|
rs121912578
|
|
Pancreatic carcinoma
|
C |
0.800 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs2900174
|
|
Pancreatic carcinoma
|
G |
0.800 |
GeneticVariation
|
GWASCAT |
Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study.
|
28470677 |
2017 |
|
rs2900174
|
|
Pancreatic carcinoma
|
G |
0.800 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
|
22142827 |
2012 |
|
rs2900174
|
|
Pancreatic carcinoma
|
G |
0.800 |
GeneticVariation
|
GWASDB |
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
|
22142827 |
2012 |
|
rs763780
|
|
Pancreatic carcinoma
|
G |
0.800 |
GeneticVariation
|
GWASCAT |
Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study.
|
28470677 |
2017 |
|
rs763780
|
|
Pancreatic carcinoma
|
G |
0.800 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
|
22142827 |
2012 |
|
rs763780
|
|
Pancreatic carcinoma
|
G |
0.800 |
GeneticVariation
|
GWASDB |
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
|
22142827 |
2012 |
|
rs121913529
|
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Importantly, FGTI-2734 inhibited the growth of xenografts derived from four patients with pancreatic cancer with mutant KRAS (2 G12D and 2 G12V) tumors.
|
31227505 |
2019 |
|
rs121913529
|
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
KRAS G12D point mutation plays an important role in the incidence of non-small-cell lung cancer (NSCLC) as well as colorectal cancer, pancreatic cancer and breast cancer.
|
30876538 |
2019 |
|
rs121913529
|
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Oncogene-directed increased expression of Nrf2 is a new mechanism for the activation of the Nrf2 antioxidant program, and is evident in primary cells and tissues of mice expressing K-Ras(G12D) and B-Raf(V619E), and in human pancreatic cancer.
|
21734707 |
2011 |
|
rs121913529
|
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
We find that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer.
|
14706336 |
2003 |
|
rs121913529
|
|
Pancreatic carcinoma
|
A |
0.740 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs121913529
|
|
Pancreatic carcinoma
|
T |
0.740 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs401681
|
|
Pancreatic carcinoma
|
T |
0.740 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
|
29422604 |
2018 |
|
rs401681
|
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that T allele of CLPTM1L-telomerase reverse transcriptase rs401681 polymorphism is associated with an increased PC risk, especially among Chinese.
|
25284078 |
2015 |
|
rs401681
|
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
A small number of common susceptibility loci have been identified for pancreatic cancer, one of which is marked by rs401681 in the TERT-CLPTM1L gene region on chromosome 5p15.33.
|
25940397 |
2015 |
|
rs401681
|
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
GWASCAT |
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
|
26098869 |
2015 |
|
rs401681
|
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Our data suggests that the T allele of rs401681 in CLPTM1L-TERT locus predisposes its carriers to pancreatic cancer, and further research into the function of CLPTM1L-TERT locus and its potential biological mechanism association may be warranted.
|
24577890 |
2014 |
|
rs401681
|
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
These findings suggested that rs401681 C allele was a low-penetrance risk allele for the development of cancers of lung, bladder, prostate and basal cell carcinoma, but a potential protective allele for melanoma and pancreatic cancer.
|
23226346 |
2012 |
|
rs401681
|
|
Pancreatic carcinoma
|
T |
0.740 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.
|
20101243 |
2010 |
|
rs505922
|
|
Pancreatic carcinoma
|
C |
0.740 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
|
29422604 |
2018 |
|
rs505922
|
|
Pancreatic carcinoma
|
|
0.740 |
GeneticVariation
|
GWASCAT |
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
|
26098869 |
2015 |