rs11824092
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.020 |
GeneticVariation
|
BEFREE |
The main positive findings refer to associations between selected polymorphisms and: 1) chronotype with the ARNTL gene (rs11824092 and rs1481892) and the CLOCK (rs1268271) 2) sleep duration with the CLOCK gene (rs3805148) and the TIM gene (rs2291739) 3) daytime dysfunction with the PER3 gene (rs228727, rs228642, rs10864315) 4) subjective sleep quality with the ARNTL gene (rs11824092, rs1982350) 5) sleep disturbances with the ARNTL gene (rs11600996) We also found the significant epistatic interactions between polymorphism of the PER3 gene (rs2640909) & the CLOCK gene (rs11932595) and following sleep quality variables: sleep duration, habitual sleep efficiency and subjective sleep quality.
|
27102916 |
2016 |
rs11824092
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.020 |
GeneticVariation
|
BEFREE |
In epistatic interaction analyses, we observed two locus interactions between sleep disturbances (p = 0.007; rs11824092 of ARNTL and rs11932595 of CLOCK) as well as interactions of subdimension in main depression and ARNTL variants (p = 0.0011; rs3789327, rs10766075) and appetite disturbances in depression and ARNTL polymorphism (p = 7 × 10(-4); rs11022778, rs156243).
|
24673294 |
2014 |
rs11932595
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.020 |
GeneticVariation
|
BEFREE |
The main positive findings refer to associations between selected polymorphisms and: 1) chronotype with the ARNTL gene (rs11824092 and rs1481892) and the CLOCK (rs1268271) 2) sleep duration with the CLOCK gene (rs3805148) and the TIM gene (rs2291739) 3) daytime dysfunction with the PER3 gene (rs228727, rs228642, rs10864315) 4) subjective sleep quality with the ARNTL gene (rs11824092, rs1982350) 5) sleep disturbances with the ARNTL gene (rs11600996) We also found the significant epistatic interactions between polymorphism of the PER3 gene (rs2640909) & the CLOCK gene (rs11932595) and following sleep quality variables: sleep duration, habitual sleep efficiency and subjective sleep quality.
|
27102916 |
2016 |
rs11932595
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.020 |
GeneticVariation
|
BEFREE |
In epistatic interaction analyses, we observed two locus interactions between sleep disturbances (p = 0.007; rs11824092 of ARNTL and rs11932595 of CLOCK) as well as interactions of subdimension in main depression and ARNTL variants (p = 0.0011; rs3789327, rs10766075) and appetite disturbances in depression and ARNTL polymorphism (p = 7 × 10(-4); rs11022778, rs156243).
|
24673294 |
2014 |
rs104893877
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
Neuronal expression of familial Parkinson's disease A53T α-synuclein causes early motor impairment, reduced anxiety and potential sleep disturbances in mice.
|
23938351 |
2013 |
rs10766075
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
In epistatic interaction analyses, we observed two locus interactions between sleep disturbances (p = 0.007; rs11824092 of ARNTL and rs11932595 of CLOCK) as well as interactions of subdimension in main depression and ARNTL variants (p = 0.0011; rs3789327, rs10766075) and appetite disturbances in depression and ARNTL polymorphism (p = 7 × 10(-4); rs11022778, rs156243).
|
24673294 |
2014 |
rs10830963
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings do not support participation of the MTNR1B gene variant rs10830963 in the well documented association between sleep disturbances and type 2 diabetes.
|
21380592 |
2011 |
rs10864315
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
The main positive findings refer to associations between selected polymorphisms and: 1) chronotype with the ARNTL gene (rs11824092 and rs1481892) and the CLOCK (rs1268271) 2) sleep duration with the CLOCK gene (rs3805148) and the TIM gene (rs2291739) 3) daytime dysfunction with the PER3 gene (rs228727, rs228642, rs10864315) 4) subjective sleep quality with the ARNTL gene (rs11824092, rs1982350) 5) sleep disturbances with the ARNTL gene (rs11600996) We also found the significant epistatic interactions between polymorphism of the PER3 gene (rs2640909) & the CLOCK gene (rs11932595) and following sleep quality variables: sleep duration, habitual sleep efficiency and subjective sleep quality.
|
27102916 |
2016 |
rs11022778
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
In epistatic interaction analyses, we observed two locus interactions between sleep disturbances (p = 0.007; rs11824092 of ARNTL and rs11932595 of CLOCK) as well as interactions of subdimension in main depression and ARNTL variants (p = 0.0011; rs3789327, rs10766075) and appetite disturbances in depression and ARNTL polymorphism (p = 7 × 10(-4); rs11022778, rs156243).
|
24673294 |
2014 |
rs11600996
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
The main positive findings refer to associations between selected polymorphisms and: 1) chronotype with the ARNTL gene (rs11824092 and rs1481892) and the CLOCK (rs1268271) 2) sleep duration with the CLOCK gene (rs3805148) and the TIM gene (rs2291739) 3) daytime dysfunction with the PER3 gene (rs228727, rs228642, rs10864315) 4) subjective sleep quality with the ARNTL gene (rs11824092, rs1982350) 5) sleep disturbances with the ARNTL gene (rs11600996) We also found the significant epistatic interactions between polymorphism of the PER3 gene (rs2640909) & the CLOCK gene (rs11932595) and following sleep quality variables: sleep duration, habitual sleep efficiency and subjective sleep quality.
|
27102916 |
2016 |
rs1481318368
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
Neuronal expression of familial Parkinson's disease A53T α-synuclein causes early motor impairment, reduced anxiety and potential sleep disturbances in mice.
|
23938351 |
2013 |
rs1481892
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
The main positive findings refer to associations between selected polymorphisms and: 1) chronotype with the ARNTL gene (rs11824092 and rs1481892) and the CLOCK (rs1268271) 2) sleep duration with the CLOCK gene (rs3805148) and the TIM gene (rs2291739) 3) daytime dysfunction with the PER3 gene (rs228727, rs228642, rs10864315) 4) subjective sleep quality with the ARNTL gene (rs11824092, rs1982350) 5) sleep disturbances with the ARNTL gene (rs11600996) We also found the significant epistatic interactions between polymorphism of the PER3 gene (rs2640909) & the CLOCK gene (rs11932595) and following sleep quality variables: sleep duration, habitual sleep efficiency and subjective sleep quality.
|
27102916 |
2016 |
rs156243
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
In epistatic interaction analyses, we observed two locus interactions between sleep disturbances (p = 0.007; rs11824092 of ARNTL and rs11932595 of CLOCK) as well as interactions of subdimension in main depression and ARNTL variants (p = 0.0011; rs3789327, rs10766075) and appetite disturbances in depression and ARNTL polymorphism (p = 7 × 10(-4); rs11022778, rs156243).
|
24673294 |
2014 |
rs1801260
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP) in the 3'-flanking region of CLOCK (3111T/C; rs1801260) has been reported to be associated with sleep disturbances and an increased recurrence rate in patients with bipolar disorder.
|
20600471 |
2010 |
rs1982350
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
The main positive findings refer to associations between selected polymorphisms and: 1) chronotype with the ARNTL gene (rs11824092 and rs1481892) and the CLOCK (rs1268271) 2) sleep duration with the CLOCK gene (rs3805148) and the TIM gene (rs2291739) 3) daytime dysfunction with the PER3 gene (rs228727, rs228642, rs10864315) 4) subjective sleep quality with the ARNTL gene (rs11824092, rs1982350) 5) sleep disturbances with the ARNTL gene (rs11600996) We also found the significant epistatic interactions between polymorphism of the PER3 gene (rs2640909) & the CLOCK gene (rs11932595) and following sleep quality variables: sleep duration, habitual sleep efficiency and subjective sleep quality.
|
27102916 |
2016 |
rs2230912
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetically engineered mice, with human P2X7R, revealed that heterozygous mice (i.e., they coexpress the disease-associated Gln460Arg variant together with its normal version) have impaired receptor function and showed sleep disturbances.
|
29079688 |
2017 |
rs2291739
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
The main positive findings refer to associations between selected polymorphisms and: 1) chronotype with the ARNTL gene (rs11824092 and rs1481892) and the CLOCK (rs1268271) 2) sleep duration with the CLOCK gene (rs3805148) and the TIM gene (rs2291739) 3) daytime dysfunction with the PER3 gene (rs228727, rs228642, rs10864315) 4) subjective sleep quality with the ARNTL gene (rs11824092, rs1982350) 5) sleep disturbances with the ARNTL gene (rs11600996) We also found the significant epistatic interactions between polymorphism of the PER3 gene (rs2640909) & the CLOCK gene (rs11932595) and following sleep quality variables: sleep duration, habitual sleep efficiency and subjective sleep quality.
|
27102916 |
2016 |
rs2640909
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
The main positive findings refer to associations between selected polymorphisms and: 1) chronotype with the ARNTL gene (rs11824092 and rs1481892) and the CLOCK (rs1268271) 2) sleep duration with the CLOCK gene (rs3805148) and the TIM gene (rs2291739) 3) daytime dysfunction with the PER3 gene (rs228727, rs228642, rs10864315) 4) subjective sleep quality with the ARNTL gene (rs11824092, rs1982350) 5) sleep disturbances with the ARNTL gene (rs11600996) We also found the significant epistatic interactions between polymorphism of the PER3 gene (rs2640909) & the CLOCK gene (rs11932595) and following sleep quality variables: sleep duration, habitual sleep efficiency and subjective sleep quality.
|
27102916 |
2016 |
rs28934906
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two brothers with T158M mutations and normal karyotype had a severe early onset encephalopathy, progressive microcephaly, severe feeding problems, breathing and sleep disturbances.
|
17236109 |
2006 |
rs34637584
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
Neuropsychiatric, dysautonomic and sleep disturbances occur as frequently in patients with LRRK2-G2019S-PD as in IPD but smell loss was less frequent in LRRK2-PD.
|
25330404 |
2014 |
rs3789327
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
In epistatic interaction analyses, we observed two locus interactions between sleep disturbances (p = 0.007; rs11824092 of ARNTL and rs11932595 of CLOCK) as well as interactions of subdimension in main depression and ARNTL variants (p = 0.0011; rs3789327, rs10766075) and appetite disturbances in depression and ARNTL polymorphism (p = 7 × 10(-4); rs11022778, rs156243).
|
24673294 |
2014 |
rs3805148
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
The main positive findings refer to associations between selected polymorphisms and: 1) chronotype with the ARNTL gene (rs11824092 and rs1481892) and the CLOCK (rs1268271) 2) sleep duration with the CLOCK gene (rs3805148) and the TIM gene (rs2291739) 3) daytime dysfunction with the PER3 gene (rs228727, rs228642, rs10864315) 4) subjective sleep quality with the ARNTL gene (rs11824092, rs1982350) 5) sleep disturbances with the ARNTL gene (rs11600996) We also found the significant epistatic interactions between polymorphism of the PER3 gene (rs2640909) & the CLOCK gene (rs11932595) and following sleep quality variables: sleep duration, habitual sleep efficiency and subjective sleep quality.
|
27102916 |
2016 |
rs61751362
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
We were surprised to find associations between the p.Arg294* mutation and some sleep disturbances given that other aspects of its phenotype are milder.
|
27255190 |
2016 |
rs671
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition to the genotypes of rs671, the patients were assessed with the PD sleep scale-2nd version (PDSS-2) and the Epworth sleepiness scale (ESS) for symptoms of daytime and nocturnal sleep disturbances.
|
31831791 |
2019 |
rs738499
|
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
|
0.010 |
GeneticVariation
|
BEFREE |
These preliminary results suggest that the TT genotype in Tef rs738499 is associated with sleep disturbances in PD.
|
22257907 |
2012 |