rs1143623
|
|
Interleukin 1 Beta Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation.
|
30206230 |
2018 |
rs1143627
|
|
Interleukin 1 Beta Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation.
|
30206230 |
2018 |
rs1143627
|
|
GASTRIC CANCER SUSCEPTIBILITY AFTER H. PYLORI INFECTION
|
A |
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
rs1143633
|
|
Allergic Reaction
|
C |
0.700 |
GeneticVariation
|
GWASCAT |
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
|
29083406 |
2017 |
rs1143634
|
|
Interleukin 1 Beta Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation.
|
30206230 |
2018 |
rs16944
|
|
Interleukin 1 Beta Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation.
|
30206230 |
2018 |
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Peroxynitrite Activates the NLRP3 Inflammasome Cascade in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.
|
28357805 |
2018 |
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PRR NLRC4, caspase 1 and IL1β were significantly elevated in denervated muscle of SOD1<sup>(G93A)</sup> mice and sALS patients.
|
29575052 |
2018 |
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Neurodegeneration and NLRP3 inflammasome expression in the anterior thalamus of SOD1(G93A) ALS mice.
|
27880990 |
2018 |
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Inflammasome activation was recently shown in the spinal cord of human sporadic ALS patients and in the SOD1(G93A) mouse model for ALS.
|
27957680 |
2017 |
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we investigated the expression, activation and co-localization of the NLRP3 inflammasome in the spinal cord of male SOD1(G93A) mice carrying a mutant human superoxide dismutase 1 (SOD1) variant and regarded as an animal model for ALS as well as in post-mortem tissue of ALS patients.
|
26200799 |
2015 |
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we show the therapeutic benefits of a modified peptide agonist stearyl-norleucine-VIP (SNV) in a transgenic rat model of amyotrophic lateral sclerosis (mutated superoxide dismutase 1, hSOD1(G93A)).
|
25311268 |
2015 |
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Erythropoietin modulates the immune-inflammatory response of a SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).
|
24820540 |
2014 |
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, to investigate the role of proliferating cells in motor neuron disease, SOD1(G93A) transgenic mice were treated intracerebroventicularly (i.c.v.) with the anti-mitotic drug cytosine arabinoside (Ara-C).I.c.v. delivery of Ara-C accelerated disease progression in SOD1(G93A) mouse model of ALS.
|
22523565 |
2012 |
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We show here that the expression of caspase-11 is upregulated in the spinal cord of superoxide dismutase 1 (SOD1) G93A transgenic mice, a mouse model of amyotrophic lateral sclerosis (ALS), before the onset of motor dysfunction and remains at the high levels throughout the course of disease.
|
12843244 |
2003 |
rs1445888481
|
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.
|
12124437 |
2002 |
rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
We have found a trend toward an association of rs1143627, rs16944, rs1143623 in IL1B gene with the risk of schizophrenia.
|
28083609 |
2016 |
rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
Moreover, our meta-analysis results showed no significant association between the common SNV, rs16944, and schizophrenia.
|
24155145 |
2014 |
rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
The present study examined the effects of a functional polymorphism at IL1B gene promoter (-511C/T; rs16944) on brain correlates of working memory performance in schizophrenia.
|
22763186 |
2012 |
rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
A trend towards association was also found between rs16944 and female patients with schizophrenia (P = 0.032).
|
21843369 |
2011 |
rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
The combined allele-wise odds ratio (OR) for schizophrenia of the rs16944 (IL1B gene; T-511C) polymorphism was 0.86 (95% CI: 0.77to 0.96).When applying stratified analysis to this polymorphism, the pooled allele-wise OR was 0.88 (95% CI, 0.79 to 0.97) in 10 population-based studies and 0.85 (95% CI: 0.73 to 0.99) in Caucasian samples.
|
20347268 |
2010 |
rs16944
|
|
Schizophrenia
|
|
0.060 |
GeneticVariation
|
BEFREE |
However, meta-analysis of our data combined with previously published association studies of rs16944 (IL1beta -511) suggests that the C allele confers modest risk for schizophrenia among individuals reporting Caucasian ancestry, but not Asians (Caucasians, n=819 cases, 1292 controls; p=0.0013, OR=1.24, 95% CI 1.09, 1.41).
|
16905295 |
2006 |
rs1143634
|
|
Chronic Periodontitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found that the statistically significant association of IL1A-889C/T (rs1800587), IL1B -31C/T (rs1143627), IL1B -511A/G (rs16944) and IL1B + 3954C/T (rs1143634) gene polymorphisms with increased susceptibility of chronic periodontitis.
|
30939298 |
2019 |
rs1143634
|
|
Chronic Periodontitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis in 9376 participants with 54 case/control studies revealed the rs1143634 polymorphism was associated with elevated risk of chronic periodontitis in overall analysis as well as Caucasian and Asian ethnicities and Mixed population.
|
29783069 |
2018 |
rs1143634
|
|
Chronic Periodontitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
In conclusion, literature review suggests that for IL1B SNP rs1143634, EARR and CP have an opposite genetic profile.
|
30142580 |
2018 |