|
rs7023329
|
|
melanoma
|
|
0.810 |
GeneticVariation
|
BEFREE |
One SNP in MTAP (methylthioadenosine phosphorylase) (rs7023329) that was previously associated with melanoma and nevi in multiple genome-wide association studies was associated with CRC, CA and OS by ASSET (P=0.007).
|
23361049 |
2013 |
|
rs10757257
|
|
melanoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
In addition, variants in these two loci showed association with melanoma risk in 3,131 melanoma cases from two independent studies, including rs10757257 at 9p21, combined P = 3.4 x 10(-8), OR = 1.23 (95% CI = 1.15-1.30) and rs132985 at 22q13.1, combined P = 2.6 x 10(-7), OR = 1.23 (95% CI = 1.15-1.30).
|
19578365 |
2009 |
|
rs10118757
|
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our study firstly reported that SNP rs10118757 was associated with CAD risk in a Chinese Han population, indicating that MTAP gene may play a potential role in the pathophysiological process of CAD.
|
23462334 |
2013 |
|
rs10118757
|
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Eight SNPs (rs11206510, rs10118757, rs2383206, rs501120, rs2075292, rs174547, rs173539, and rs255052) were nominally significantly associated with CAD (P<0.05), and 5 of them were newly reported.
|
22664640 |
2012 |
|
rs10118757
|
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
As reported previously, rs10118757 was not associated with MI in the current study.
|
23462334 |
2013 |
|
rs10118757
|
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association between rs10118757(A/G) in methylthioadenosine phosphorylase gene and coronary artery disease in Chinese Hans.
|
23462334 |
2013 |
|
rs10118757
|
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association between rs10118757(A/G) in methylthioadenosine phosphorylase gene and coronary artery disease in Chinese Hans.
|
23462334 |
2013 |
|
rs10118757
|
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further, we also observed the combined effects of rs10118757 with alcohol drinking and hypertension, which increased the risk of i</span>schemic stroke.
|
19427650 |
2009 |
|
rs10118757
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Further, we also observed the combined effects of rs10118757 with alcohol drinking and hypertension, which increased the risk of ischemic stroke.
|
19427650 |
2009 |
|
rs10118757
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
The G allele of rs10118757 was associated with an increased risk of stroke, with a per-allele OR of 1.31(95% CI, 1.04-1.65, p=0.025).
|
19427650 |
2009 |
|
rs10757257
|
|
Lentigo maligna melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, MTAP rs10757257 was associated with superficial spreading/nodular melanoma (OR = 1.34, 95% CI = 1.15- 1.57), but not with lentigo maligna melanoma (OR = 0.79, 95% CI = 0.46-1.35) (Phomogeneity =.06), the subtype associated with chronic sun exposure.
|
21962134 |
2011 |
|
rs10757257
|
|
Nodular melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, MTAP rs10757257 was associated with superficial spreading/nodular melanoma (OR = 1.34, 95% CI = 1.15- 1.57), but not with lentigo maligna melanoma (OR = 0.79, 95% CI = 0.46-1.35) (Phomogeneity =.06), the subtype associated with chronic sun exposure.
|
21962134 |
2011 |
|
rs7023329
|
|
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the G allele of rs7023329 was significantly associated with a decreased risk of ESCC with a per-allele odds ratio of 0.84 (95% confidence interval, 0.77-0.91; P = 2.95 × 10<sup>-5</sup> ).
|
27960044 |
2017 |
|
rs7023329
|
|
Osteosarcoma of bone
|
|
0.010 |
GeneticVariation
|
BEFREE |
One SNP in MTAP (methylthioadenosine phosphorylase) (rs7023329) that was previously associated with melanoma and nevi in multiple genome-wide association studies was associated with CRC, CA and OS by ASSET (P=0.007).
|
23361049 |
2013 |
|
rs7023329
|
|
Osteosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
One SNP in MTAP (methylthioadenosine phosphorylase) (rs7023329) that was previously associated with melanoma and nevi in multiple genome-wide association studies was associated with CRC, CA and OS by ASSET (P=0.007).
|
23361049 |
2013 |
|
rs7023329
|
|
Childhood Osteosarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
One SNP in MTAP (methylthioadenosine phosphorylase) (rs7023329) that was previously associated with melanoma and nevi in multiple genome-wide association studies was associated with CRC, CA and OS by ASSET (P=0.007).
|
23361049 |
2013 |
|
rs7023329
|
|
Adenoma of large intestine
|
|
0.010 |
GeneticVariation
|
BEFREE |
One SNP in MTAP (methylthioadenosine phosphorylase) (rs7023329) that was previously associated with melanoma and nevi in multiple genome-wide association studies was associated with CRC, CA and OS by ASSET (P=0.007).
|
23361049 |
2013 |
|
rs7023329
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
We used a family-based association test for five previously identified cancer-susceptibility tag single-nucleotide polymorphisms (rs1063192, rs2151280, rs2218220, rs10757257, and rs7023329) located in chromosomal region 9p21.3 in 1105 subjects (740 NF1 patients and 365 non-affected relatives) from 306 families.
|
22034633 |
2011 |
|
rs7023329
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
We used a family-based association test for five previously identified cancer-susceptibility tag single-nucleotide polymorphisms (rs1063192, rs2151280, rs2218220, rs10757257, and rs7023329) located in chromosomal region 9p21.3 in 1105 subjects (740 NF1 patients and 365 non-affected relatives) from 306 families.
|
22034633 |
2011 |
|
rs7023954
|
|
melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Characterization of the Methylthioadenosine Phosphorylase Polymorphism rs7023954 - Incidence and Effects on Enzymatic Function in Malignant Melanoma.
|
27479139 |
2016 |
|
rs7027989
|
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed that rs7027989 in the MTAP gene, and rs3217992 and rs1063192 in the CDKN2B gene were significantly associated with MI in male subjects.
|
19272367 |
2009 |
|
rs869329
|
|
melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Individuals having melanoma in a visibly UV-damaged site were more likely to carry MC1R rs75570604 (odds ratio [OR] 2.5), 9q31.2 rs10816595 (OR 2.5), and MTAP rs869329 (OR 1.4); these same alleles were more common in MPM patients diagnosed ≤40 years.
|
31794051 |
2019 |
|
rs869330
|
|
Cutaneous Melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This exploratory study is the first to show a significant association between the rs869330 variant (in the MTAP gene) and outcome in a large CM population.
|
30681428 |
2019 |
|
rs869330
|
|
melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This exploratory study is the first to show a significant association between the rs869330 variant (in the MTAP gene) and outcome in a large CM population.
|
30681428 |
2019 |