Source: GWASDB

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		T 0.810 GeneticVariation GWASDB New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population. 23575436

2013
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0001948
Disease: Alcohol consumption
Alcohol consumption 		0.800 GeneticVariation GWASDB Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population. 23555315

2013
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0005845
Disease: Blood urea nitrogen measurement
Blood urea nitrogen measurement 		A 0.800 GeneticVariation GWASDB Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. 22797727

2012
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		T 0.800 GeneticVariation GWASDB Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. 21909109

2011
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0001948
Disease: Alcohol consumption
Alcohol consumption 		T 0.800 GeneticVariation GWASDB Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. 21270382

2011
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.800 GeneticVariation GWASDB Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. 20833657

2010
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0205682
Disease: Waist-Hip Ratio
Waist-Hip Ratio 		T 0.800 GeneticVariation GWASDB For waist-hip ratio, variants on chromosome 12q24 (rs2074356, P = 7.8 x 10(-12)) showed convincing associations, although no regional transcript has strong biological candidacy. 19396169

2009
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.700 GeneticVariation GWASDB Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. 23377640

2013
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.700 GeneticVariation GWASDB A genome-wide association study of a coronary artery disease risk variant. 23364394

2013
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0013124
Disease: Drinking behavior processes
Drinking behavior processes 		0.700 GeneticVariation GWASDB Common variants at 12q24 are associated with drinking behavior in Han Chinese. 23364009

2013
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.700 GeneticVariation GWASDB Genome-wide association study of coronary artery disease in the Japanese. 21971053

2012
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0428472
Disease: Serum HDL cholesterol measurement
Serum HDL cholesterol measurement 		T 0.700 GeneticVariation GWASDB Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. 21909109

2011
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0202035
Disease: Gamma glutamyl transferase measurement
Gamma glutamyl transferase measurement 		T 0.700 GeneticVariation GWASDB Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. 21909109

2011
dbSNP: rs2074356
rs2074356
HECTD4
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus 		T 0.700 GeneticVariation GWASDB Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. 21642993

2011