|
rs2856718
|
|
Hepatitis B
|
|
0.860 |
GeneticVariation
|
BEFREE |
These results indicate that rs9277535 and rs3077 in HLA-DP are the major determinants of response to hepatitis B vaccine, whereas rs2856718 and rs7453920 in HLA-DQ have little effect on the immune response to hepatitis B vaccine.
|
28882445 |
2017 |
|
rs2856718
|
|
Hepatitis B
|
|
0.860 |
GeneticVariation
|
BEFREE |
SNPs of HLA-DPA1 (rs3077), HLA-DPB1 (rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2 (rs7453920) were determined, and HBV genotyping was performed by phylogenetic analysis in HBV patients.
|
28267888 |
2017 |
|
rs2856718
|
|
Hepatitis B
|
|
0.860 |
GeneticVariation
|
BEFREE |
The pooled data showed that HLA-DQ rs2856718-G polymorphism showed protection against HBV infection, and rs2856718-A was a risk factor for chronic HBV infection.
|
28512640 |
2017 |
|
rs2856718
|
|
Hepatitis B
|
|
0.860 |
GeneticVariation
|
BEFREE |
In 224 hepatitis B e antigen (HBeAg)-negative patients, those with rs2856718 genotype AG + GG had significantly lower hepatitis B core-related antigen levels (P = 0.0184), less frequent treatment with nucleotide/nucleoside analogs (NAs) (P = 0.0433), and less frequent HCC development (P = 0.0256) than those with genotype AA.
|
27580643 |
2017 |
|
rs2856718
|
|
Hepatitis B
|
|
0.860 |
GeneticVariation
|
BEFREE |
Several recent genome-wide studies showed that the genetic polymorphisms in the HLA-DQ region (rs9275572 and rs2856718) were related to chronic hepatitis B virus (HBV) infection and chronic hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC).
|
27209411 |
2016 |
|
rs2856718
|
|
Hepatitis B
|
|
0.860 |
GeneticVariation
|
GWASDB |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
rs2856718
|
|
Hepatitis B
|
|
0.860 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies showed that four single-nucleotide polymorphisms (SNPs) in human leukocyte antigen (HLA)-DP (rs3077 and rs9277535) and HLA-DQ (rs2856718 and rs7453920) were associated with chronic hepatitis B virus (HBV) infection in Japanese populations.
|
22105689 |
2012 |
|
rs2856718
|
|
Hepatitis B
|
A |
0.860 |
GeneticVariation
|
GWASDB |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
rs2856718
|
|
Hepatitis B
|
A |
0.860 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
rs2856718
|
|
Liver carcinoma
|
|
0.750 |
GeneticVariation
|
BEFREE |
We found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian.
|
28761441 |
2017 |
|
rs2856718
|
|
Liver carcinoma
|
|
0.750 |
GeneticVariation
|
BEFREE |
This study revealed an association between rs2856718 and HCC development and an association between rs7453920 and HBsAg levels.
|
27580643 |
2017 |
|
rs2856718
|
|
Liver carcinoma
|
|
0.750 |
GeneticVariation
|
BEFREE |
Several recent genome-wide studies showed that the genetic polymorphisms in the HLA-DQ region (rs9275572 and rs2856718) were related to chronic hepatitis B virus (HBV) infection and chronic hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC).
|
27209411 |
2016 |
|
rs2856718
|
|
Liver carcinoma
|
|
0.750 |
GeneticVariation
|
BEFREE |
Two recent genome-wide studies showed that the single-nucleotide polymorphisms in the HLA-DQ region (rs2856718 and rs9275572) were associated with chronic hepatitis B virus infection and chronic hepatitis C virus-associated hepatocellular carcinoma in Japanese patients.
|
24750255 |
2014 |
|
rs2856718
|
|
Liver carcinoma
|
|
0.750 |
GeneticVariation
|
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
rs2856718
|
|
Liver carcinoma
|
|
0.750 |
GeneticVariation
|
BEFREE |
Logistic regression analyses showed that HLA-DQ rs2856718 significantly decreased host HCC risk, whereas three SNPs were associated with HBV clearance (HLA-DP rs9277535 as well as HLA-DQ rs7453920 and rs2856718).
|
22105689 |
2012 |
|
rs2856718
|
|
Hepatitis B, Chronic
|
|
0.730 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance.
|
28882445 |
2017 |
|
rs2856718
|
|
Hepatitis B, Chronic
|
C |
0.730 |
GeneticVariation
|
GWASCAT |
Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.
|
25802187 |
2015 |
|
rs2856718
|
|
Hepatitis B, Chronic
|
|
0.730 |
GeneticVariation
|
BEFREE |
Two recent genome-wide studies showed that the single-nucleotide polymorphisms in the HLA-DQ region (rs2856718 and rs9275572) were associated with chronic hepatitis B virus infection and chronic hepatitis C virus-associated hepatocellular carcinoma in Japanese patients.
|
24750255 |
2014 |
|
rs2856718
|
|
Hepatitis B, Chronic
|
|
0.730 |
GeneticVariation
|
BEFREE |
We aimed to determine impacts of HLA-DQ polymorphisms and their interactions with HBV mutations on the risks of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). rs2856718 (A>G) and rs9275319 (A>G) were genotyped in 1342 healthy controls, 327 HBV surface antigen (HBsAg) seroclearance subjects, 611 asymptomatic HBsAg carriers (ASCs), 1144 chronic hepatitis B (CHB) patients, 734 LC patients, and 1531 HCC patients using quantitative PCR.
|
25281206 |
2014 |
|
rs2856718
|
|
Hepatitis B, Chronic
|
|
0.730 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
rs2856718
|
|
Lupus Erythematosus, Systemic
|
C |
0.700 |
GeneticVariation
|
GWASDB |
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
|
24871463 |
2014 |
|
rs2856718
|
|
Allergic Reaction
|
T |
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
|
23817569 |
2013 |
|
rs2856718
|
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
rs2856718
|
|
Hepatitis C
|
|
0.020 |
GeneticVariation
|
BEFREE |
Several recent genome-wide studies showed that the genetic polymorphisms in the HLA-DQ region (rs9275572 and rs2856718) were related to chronic hepatitis B virus (HBV) infection and chronic hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC).
|
27209411 |
2016 |
|
rs2856718
|
|
Hepatitis C
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results indicated that the genetic variations of rs2856718 within the HLA-DQ gene are associated with the natural susceptibility to HCV infection among the Chinese population.
|
26213920 |
2015 |