|
rs3850641
|
|
Myocardial Infarction
|
|
0.060 |
GeneticVariation
|
BEFREE |
When we stratified eligible studies by type of disease, positive results were observed for rs17568 variant in subjects with acute coronary syndrome (ACS) (allele model: P = 0.04, OR = 0.81, 95%CI, 0.65-0.99), for rs1234314 variant in subjects with coronary artery disease (CAD) (dominant model: P = 0.04, OR = 1.16, 95%CI, 1.00-1.35), for rs3850641 variant in subjects with CAD (recessive model: P = 0.02, OR = 1.42, 95%CI, 1.05-1.90) and myocardial infarction (MI) (recessive model: P = 0.03, OR = 1.49, 95%CI, 1.05-2.11).
|
30614039 |
2019 |
|
rs3850641
|
|
Myocardial Infarction
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, this case-control study confirms that the rs3850641 polymorphism of the TNFSF4 gene increases the risk of MI.
|
29921578 |
2018 |
|
rs3850641
|
|
Myocardial Infarction
|
|
0.060 |
GeneticVariation
|
BEFREE |
We investigated the influence of 5 TNFSF4 tagging single nucleotide polymorphisms (rs3861950, rs17346501, rs7518045, rs1234313, and rs3850641) on individual susceptibility to MI in a Chinese population of 285 MI patients and 645 controls.
|
26125814 |
2015 |
|
rs3850641
|
|
Myocardial Infarction
|
|
0.060 |
GeneticVariation
|
BEFREE |
Recent studies indicate that the single nucleotide polymorphism (SNP) rs3850641 in TNFSF4 is associated with higher risk of myocardial infarction, but little is known about the association between TNFSF4 variation and cerebral infarction (CI).
|
23184501 |
2013 |
|
rs3850641
|
|
Myocardial Infarction
|
|
0.060 |
GeneticVariation
|
BEFREE |
In two independent human cohorts, the minor allele of SNP rs3850641 in TNFSF4 was significantly more frequent in individuals with myocardial infarction than in controls.
|
18998106 |
2009 |
|
rs3850641
|
|
Myocardial Infarction
|
|
0.060 |
GeneticVariation
|
BEFREE |
In two independent human populations, the less common allele of SNP rs3850641 in TNFSF4 was significantly more frequent (P <or= 0.05) in individuals with myocardial infarction than in controls.
|
15750594 |
2005 |
|
rs3850641
|
|
Acute Chest Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
When we stratified eligible studies by type of disease, positive results were observed for rs17568 variant in subjects with acute coronary syndrome (ACS) (allele model: P = 0.04, OR = 0.81, 95%CI, 0.65-0.99), for rs1234314 variant in subjects with coronary artery disease (CAD) (dominant model: P = 0.04, OR = 1.16, 95%CI, 1.00-1.35), for rs3850641 variant in subjects with CAD (recessive model: P = 0.02, OR = 1.42, 95%CI, 1.05-1.90) and myocardial infarction (MI) (recessive model: P = 0.03, OR = 1.49, 95%CI, 1.05-2.11).
|
30614039 |
2019 |
|
rs3850641
|
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our findings suggested that rs17568, rs1234314, and rs3850641 variants might serve as genetic biomarkers of certain types of CAD.
|
30614039 |
2019 |
|
rs3850641
|
|
Coronary Artery Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Lack of association of tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms (rs3850641 and rs17568) with coronary heart disease and stroke: A systematic review and meta-analysis.
|
29424751 |
2018 |
|
rs3850641
|
|
Acute Chest Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
No significant association between rs2298212A/G or rs3850641A/G and the risk of ACS was found in this study.
|
21476935 |
2011 |
|
rs3850641
|
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
When we stratified eligible studies by type of disease, positive results were observed for rs17568 variant in subjects with acute coronary syndrome (ACS) (allele model: P = 0.04, OR = 0.81, 95%CI, 0.65-0.99), for rs1234314 variant in subjects with coronary artery disease (CAD) (dominant model: P = 0.04, OR = 1.16, 95%CI, 1.00-1.35), for rs3850641 variant in subjects with CAD (recessive model: P = 0.02, OR = 1.42, 95%CI, 1.05-1.90) and myocardial infarction (MI) (recessive model: P = 0.03, OR = 1.49, 95%CI, 1.05-2.11).
|
30614039 |
2019 |
|
rs3850641
|
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotypic analysis demonstrated that there was no significant association between the risk of CHD and stroke and rs3850641 [homozygous comparison (GG vs. AA): OR=1.05, 95% CI=0.74-1.50; heterozygous comparison (GA vs. AA): OR=1.00, 95% CI=0.88-1.13; recessive model (GG vs. GA+AA): OR=1.04, 95% CI=0.76-1.43; dominant model (GG+GA vs. AA): OR=1.01, 95% CI=0.88-1.17].
|
29424751 |
2018 |
|
rs3850641
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotypic analysis demonstrated that there was no significant association between the risk of CHD and stroke and rs3850641 [homozygous comparison (GG vs. AA): OR=1.05, 95% CI=0.74-1.50; heterozygous comparison (GA vs. AA): OR=1.00, 95% CI=0.88-1.13; recessive model (GG vs. GA+AA): OR=1.04, 95% CI=0.76-1.43; dominant model (GG+GA vs. AA): OR=1.01, 95% CI=0.88-1.17].
|
29424751 |
2018 |
|
rs3850641
|
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Lack of association of tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms (rs3850641 and rs17568) with coronary heart disease and stroke: A systematic review and meta-analysis.
|
29424751 |
2018 |
|
rs3850641
|
|
Hypothyroidism
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, rs3850641 variant allele G was in strong association with hypothyroidism in Hashimoto's thyroiditis (HT) (p = 0.018).
|
27556446 |
2016 |
|
rs3850641
|
|
Hashimoto Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, rs3850641 variant allele G was in strong association with hypothyroidism in Hashimoto's thyroiditis (HT) (p = 0.018).
|
27556446 |
2016 |
|
rs3850641
|
|
Atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
TNFSF4 gene polymorphism rs3861950, but not rs3850641, is associated with the risk of atherosclerosis CI in a Chinese population.
|
23184501 |
2013 |
|
rs3850641
|
|
Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
TNFSF4 gene polymorphism rs3861950, but not rs3850641, is associated with the risk of atherosclerosis CI in a Chinese population.
|
23184501 |
2013 |
|
rs3850641
|
|
Cerebral Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, there was no significant association between rs3850641 and CI (Odds ration = 1.288, 95 % confidence interval = 0.993-1.670, P = 0.056).
|
23184501 |
2013 |
|
rs3850641
|
|
Hyperlipoproteinemia Type I
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggest that the rs3850641 and rs17568 polymorphisms in the OX40L and OX40 genes are associated with some of the lipid and lipoprotein variations in subjects with endogenous HTG and/or in the general population of Han Chinese.
|
23216302 |
2013 |
|
rs3850641
|
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significant association between rs3850641 and breast cancer risk was observed under the additive model and dominant model (P = 0.01042 and 0.01942, respectively).
|
22870213 |
2012 |
|
rs3850641
|
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data primarily indicates that rs3850641 of OX40L gene contributes to sporadic breast carcinogenesis in a northeast Chinese Han population.
|
22870213 |
2012 |
|
rs3850641
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significant association between rs3850641 and breast cancer risk was observed under the additive model and dominant model (P = 0.01042 and 0.01942, respectively).
|
22870213 |
2012 |
|
rs3850641
|
|
Venous Thromboembolism
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated 2 previously characterized TNFSF4 gene variants (-921C>T and dbSNP rs3850641) with a) incident arterial events using a prospective case-cohort design with 344 incident CVD cases and 2254 control participants, all white, drawn from the Women's Health Study cohort with 10 years of follow-up, and b) venous thromboembolism (VTE) risk using a nested, matched case-control design of 108 white male pairs (drawn from the Physicians' Health Study cohort) and a case-cohort design of white female participants consisting of 125 cases and 2269 controls (drawn from the Women's Health Study cohort), analyzed separately.
|
18356244 |
2008 |