|
rs4987188
|
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
Statistically significant correlations were identified between 4 single nucleotide polymorphisms and the breast cancer risk: rs25487 rs4987188 rs13181 and rs799917.
|
29209986 |
2019 |
|
rs4987188
|
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Statistically significant correlations were identified between 4 single nucleotide polymorphisms and the breast cancer risk: rs25487 rs4987188 rs13181 and rs799917.
|
29209986 |
2019 |
|
rs4987188
|
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
MSH2-G322D likely does not cause a MMR defect, although this variant has also been associated with breast cancer as indeed seen in our patient.
|
19728162 |
2009 |
|
rs4987188
|
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
MSH2-G322D likely does not cause a MMR defect, although this variant has also been associated with breast cancer as indeed seen in our patient.
|
19728162 |
2009 |
|
rs4987188
|
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
Therefore, MMR may play a role in the breast carcinogenesis and the Gly322Asp polymorphism of the hMSH2 gene may be considered as a potential marker in breast cancer.
|
16252083 |
2005 |
|
rs4987188
|
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Therefore, MMR may play a role in the breast carcinogenesis and the Gly322Asp polymorphism of the hMSH2 gene may be considered as a potential marker in breast cancer.
|
16252083 |
2005 |
|
rs4987188
|
|
Triple Negative Breast Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Structural debilitation of mutation G322D associated with MSH2 and their role in triple negative breast cancer.
|
30806579 |
2020 |
|
rs4987188
|
|
Triple-Negative Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Structural debilitation of mutation G322D associated with MSH2 and their role in triple negative breast cancer.
|
30806579 |
2020 |
|
rs4987188
|
|
Triple Negative Breast Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Gly322Asp polymorphism of the hMSH2 gene may be linked with TNBC occurrence in Polish women.
|
25134804 |
2015 |
|
rs4987188
|
|
Triple-Negative Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Gly322Asp polymorphism of the hMSH2 gene may be linked with TNBC occurrence in Polish women.
|
25134804 |
2015 |
|
rs4987188
|
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our aim was to determine the effect of the single nucleotide polymorphisms (SNP) -93G>A of the MLH1 gene (rs1800734) and Gly322Asp of the MSH2 gene (rs4987188) on the risk of colon cancer (CC) and identify any relationship with clinical factors.
|
29181059 |
2017 |
|
rs4987188
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our aim was to determine the effect of the single nucleotide polymorphisms (SNP) -93G>A of the MLH1 gene (rs1800734) and Gly322Asp of the MSH2 gene (rs4987188) on the risk of colon cancer (CC) and identify any relationship with clinical factors.
|
29181059 |
2017 |
|
rs4987188
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
We did not observe an association between the Asn127Ser and Gly322Asp polymorphisms and cancer risk.
|
20438357 |
2010 |
|
rs4987188
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
We did not observe an association between the Asn127Ser and Gly322Asp polymorphisms and cancer risk.
|
20438357 |
2010 |
|
rs4987188
|
|
Turcot syndrome (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data demonstrate that MSH2 N127S and G322D per se are not sufficient to trigger MMR deficiency.
|
18470917 |
2008 |
|
rs4987188
|
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, MMR may play a role in the breast carcinogenesis and the Gly322Asp polymorphism of the hMSH2 gene may be considered as a potential marker in breast cancer.
|
16252083 |
2005 |
|
rs4987188
|
|
Tumor Progression
|
|
0.010 |
GeneticVariation
|
BEFREE |
We performed a case-control study to test the association between two polymorphisms in the hMSH2 gene: an A --> G transition at 127 position producing an Asn --> Ser substitution at codon 127 (the Asn127Ser polymorphism) and a G --> A transition at 1032 position resulting in a Gly --> Asp change at codon 322 (the Gly322Asp polymorphism) and breast cancer risk and cancer progression.
|
16252083 |
2005 |