|
rs6166
|
|
Polycystic Ovary Syndrome
|
|
0.090 |
GeneticVariation
|
BEFREE |
Findings of this study suggest a significant association between FSHR gene p. Thr307Ala or p. Asn680Ser coding sequence change and PCOS.
|
28547204 |
2017 |
|
rs6166
|
|
Polycystic Ovary Syndrome
|
|
0.090 |
GeneticVariation
|
BEFREE |
However, meta-analysis results showed no association between both FSHR Thr307Ala polymorphism and Asn680Ser polymorphism and susceptibility to PCOS.
|
25218548 |
2014 |
|
rs6166
|
|
Polycystic Ovary Syndrome
|
|
0.090 |
GeneticVariation
|
BEFREE |
The Ala307Thr and Ser680Asn polymorphisms of FSHR are not associated with PCOS in Han ethnic Chinese women in north China.
|
24390680 |
2014 |
|
rs6166
|
|
Polycystic Ovary Syndrome
|
|
0.090 |
GeneticVariation
|
BEFREE |
The prevalence of Asparagine680Asparagine (NN), Asparagine680Serine (NS), and Serine680Serine (SS) genotypes at codon 680 was 54.5% (95% CI = 45.7-63.2%), 40.9% (95% CI = 32.5-49.8%), and 4.5% (95% CI = 1.9-10.1%) in controls; 51.9% (95% CI = 43.1-60.6%), 44.4% (95% CI = 35.8-53.2%), and 3.8% (95% CI = 1.4-9.0%) in PCOS women; and 47.9% (95% CI = 40.4-58.8%), 47.1% (95% CI = 36.5-54.7%), and 5.0% (95% CI = 2-10.9%) in anovulatory women without PCOS, respectively.
|
25179311 |
2014 |
|
rs6166
|
|
Polycystic Ovary Syndrome
|
|
0.090 |
GeneticVariation
|
BEFREE |
Association study between FSHR Ala307Thr and Ser680Asn variants and polycystic ovary syndrome (PCOS) in Northern Chinese Han women.
|
23536150 |
2013 |
|
rs6166
|
|
Polycystic Ovary Syndrome
|
|
0.090 |
GeneticVariation
|
BEFREE |
There is no evidence that FSHR p.Asn680Ser genotypes are associated with PCOS, high AMH levels or response to clomiphene citrate.
|
22429116 |
2012 |
|
rs6166
|
|
Polycystic Ovary Syndrome
|
|
0.090 |
GeneticVariation
|
BEFREE |
Consequently, the Ser680Asn</span> polymorphism of FSHR might significantly affect PCOS patients, separately from the Ala307Thr polymorphism.
|
20514429 |
2010 |
|
rs6166
|
|
Polycystic Ovary Syndrome
|
|
0.090 |
GeneticVariation
|
BEFREE |
Meanwhile, a meta-analysis including our study (altogether six POF and eight PCOS studies) showed significant association between rs6166 marker and PCOS (p<0.05).
|
20399696 |
2010 |
|
rs6166
|
|
Polycystic Ovary Syndrome
|
|
0.090 |
GeneticVariation
|
BEFREE |
Two known polymorphisms, Thr307Ala and Ser680Asn showed similar distributions of the allelic variations and protein isoforms in PCOS and normal control subjects (n = 236).
|
11383926 |
2001 |
|
rs6166
|
|
Male infertility
|
|
0.060 |
GeneticVariation
|
BEFREE |
Then in the meta-analysis, a significant association was seen between FSHR rs6165, rs6166 polymorphisms and male infertility.
|
28764642 |
2017 |
|
rs6166
|
|
Male infertility
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our studies further confirmed reports that there were no significant associations between the FSHR Thr307Ala and Asn680Ser polymorphisms and male infertility risk.
|
26125757 |
2015 |
|
rs6166
|
|
Male infertility
|
|
0.060 |
GeneticVariation
|
BEFREE |
No statistical difference was detected in allelic distribution of the FSHR Asn680Ser between the Baltic cohort and Estonian male infertility group.
|
23413141 |
2013 |
|
rs6166
|
|
Male infertility
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, the findings demonstrate that, in Brazilian population studied, genetic variations, Asn680Ser and Thr307Ala, of the FSHR gene are not correlated with serum FSH levels or sperm count in male infertility.
|
22421444 |
2012 |
|
rs6166
|
|
Male infertility
|
|
0.060 |
GeneticVariation
|
BEFREE |
This meta-analysis supports that FSHR G-29A, Thr(307)Ala and Asn(680)Ser polymorphisms may not be capable of causing male infertility susceptibility.
|
22414334 |
2012 |
|
rs6166
|
|
Male infertility
|
|
0.060 |
GeneticVariation
|
BEFREE |
Evaluating the role of the FSH receptor gene Thr307-Ala and Asn680-Ser polymorphisms in male infertility and their association with semen quality and reproductive hormones.
|
21105990 |
2011 |
|
rs6166
|
|
Ovarian Failure, Premature
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our findings indicated that FSHR rs6166 polymorphism may serve as a potential genetic biomarker of POI in Asians, but not in other ethnicities.
|
31629411 |
2019 |
|
rs6166
|
|
Endometriosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
However, when the endometriosis group was subdivided according to fertility status and dis</span>ease stage, a positive association was found between 680Ser/Ser or GG genotype of the Asn680Ser polymorphism and fertile women with endometriosis (p = 0.004).
|
29683332 |
2018 |
|
rs6166
|
|
Endometriosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
LH (Trp8Arg/Ile15Thr), LHR (insLQ) and FSHR (Asn680Ser) polymorphisms genotypic prevalence in women with endometriosis and infertility.
|
25935136 |
2015 |
|
rs6166
|
|
Endometriosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The purpose of this study was to evaluate the influence of the follicle-stimulating hormone (FSH) receptor poymorphisms Asn680Ser and Thr307Ala on endometriosis in Turkish women.
|
25502184 |
2015 |
|
rs6166
|
|
Endometriosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
For the A/G polymorphism of FSH receptor gene (Asn680Ser), a univariate analysis for women with endometriosis demonstrated that both the GG genotype (680Ser/Ser) and GA genotype (680Ser/Asn) were associated with a significantly lower risk of endometriosis.
|
20817169 |
2011 |
|
rs6166
|
|
Ovarian Failure, Premature
|
|
0.040 |
GeneticVariation
|
BEFREE |
We observed a significant association between premature ovarian failure and the combined genetic effect of single nucleotide polymorphism (SNP) rs4646 (CA+AA) in the 3' untranslated region of CYP19A1 and the missense FSHR SNP rs6166 (AG+GG) genotype (odds ratio 5.42, 95% confidence interval 1.96-14.98), and we identified a significant association between premature ovarian failure and the combined genetic effect of the FSHR missense SNP rs6166 (AA) and the rs4646-rs10046 haplotype (C-T)+(C-C) (odds ratio 5.47, 95% confidence interval 2.03-14.75), suggesting that two biochemical pathways may be involved in the regulation of folliculogenesis.
|
21269619 |
2011 |
|
rs6166
|
|
Ovarian Failure, Premature
|
|
0.040 |
GeneticVariation
|
BEFREE |
Meanwhile, a meta-analysis including our study (altogether six POF and eight PCOS studies) showed significant association between rs6166 marker and PCOS (p<0.05).
|
20399696 |
2010 |
|
rs6166
|
|
Ovarian Failure, Premature
|
|
0.040 |
GeneticVariation
|
BEFREE |
Exon 10 had two polymorphisms, G919A and G2039A, whose allelic frequencies were 46.7% and 56.6%, respectively, in women with POF.
|
9757892 |
1998 |
|
rs6166
|
|
Premature Menopause
|
|
0.030 |
GeneticVariation
|
BEFREE |
We observed a significant association between premature ovarian failure and the combined genetic effect of single nucleotide polymorphism (SNP) rs4646 (CA+AA) in the 3' untranslated region of CYP19A1 and the missense FSHR SNP rs6166 (AG+GG) genotype (odds ratio 5.42, 95% confidence interval 1.96-14.98), and we identified a significant association between premature ovarian failure and the combined genetic effect of the FSHR missense SNP rs6166 (AA) and the rs4646-rs10046 haplotype (C-T)+(C-C) (odds ratio 5.47, 95% confidence interval 2.03-14.75), suggesting that two biochemical pathways may be involved in the regulation of folliculogenesis.
|
21269619 |
2011 |
|
rs6166
|
|
Premature Menopause
|
|
0.030 |
GeneticVariation
|
BEFREE |
Meanwhile, a meta-analysis including our study (altogether six POF and eight PCOS studies) showed significant association between rs6166 marker and PCOS (p<0.05).
|
20399696 |
2010 |