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rs6887695
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Multiple Sclerosis
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|
0.720 |
GeneticVariation
|
BEFREE |
The GG genotype of rs6887695 SNP in IL12B gene plays a role in etiopathogenesis of MS.
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28276258 |
2017 |
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rs6887695
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Multiple Sclerosis
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|
0.720 |
GeneticVariation
|
BEFREE |
Replication extended to the following polymorphisms: PKN2 (rs305217), GTF2B (rs7538427), EPHA4 (rs1517440), YTHDF3 (rs12115114), ANKFN1 (rs17758761) and PTPRM (rs4798571), which did not reach the threshold of significance in a follow-up of the first genome-wide association study (GWAS) conducted in multiple sclerosis; TMEM39A (rs1132200), which appeared as a newly identified susceptibility gene in the same study; a gene previously reaching GWAS significance in Italy, CBLB (rs9657904); IL12B (rs6887695, rs10045431), a susceptibility gene shared by diverse autoimmune diseases and, finally, another gene showing inconclusive association with multiple sclerosis, CNR1 (rs1049353).
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22194214 |
2012 |
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rs6887695
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Psoriasis
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0.100 |
GeneticVariation
|
BEFREE |
After correction for multiple testing with a false discovery rate of 5%, two SNPs remained significant: TNF (rs361525) was associated with PsO, PsC10, and PsA; and IL12B (rs6887695) was associated with PsO.
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29389950 |
2018 |
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rs6887695
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Psoriasis
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0.100 |
GeneticVariation
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BEFREE |
This study aims to assess whether the association between the non-susceptibility allelic variants of IL12B single-nucleotide polymorphism (SNPs) rs3212227 and rs6887695, IL23R SNPs rs11209026 and rs7530511, IL6 SNP rs1800795 and HLA-Cw6 could be correlated with decreased risk for psoriasis.
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24140476 |
2014 |
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rs6887695
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Psoriasis
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|
0.100 |
GeneticVariation
|
BEFREE |
Our study showed significant associations between psoriasis and both IL12B gene SNPs, rs3212227 (odds ratio (OR) = 1.35, P = 4.94E-04) and rs6887695 (OR = 1.32, P = 2.00E-03), but no significant association between psoriasis and the IL23R SNP, rs11209026.
|
23955419 |
2013 |
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rs6887695
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Psoriasis
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0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis showed that the IL-23 R (rs11209026 and rs7530511) polymorphisms are associated with psoriasis risk in Europeans and that the IL-12B (rs6887695 and rs3212227) polymorphisms are associated with susceptibility to psoriasis in Europeans.
|
23844553 |
2013 |
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rs6887695
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Psoriasis
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0.100 |
GeneticVariation
|
BEFREE |
Then, for rs6887695, the pooled ORs were 0.704 (95 % CI 0.670-0.739) for psoriasis and 0.677 (95 % CI 0.599-0.767) for PsA.
|
23297015 |
2013 |
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rs6887695
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Psoriasis
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0.100 |
GeneticVariation
|
BEFREE |
The genetic polymorphism of the IL-12B gene (rs6887695) may be associated with the psoriasis susceptibility in the Chinese Han population, especially for the plaque cases, but not associated with the age at onset, family history, or sex.
|
23564024 |
2013 |
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rs6887695
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Psoriasis
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|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the relationships of these predisposing polymorphisms with psoriasis in the Chinese Han population, we genotyped three representative variants (rs6887695</span>, rs11465817, and rs1343152) in 217 unrelated patients and 288 control subjects using direct sequencing, We further replicated the positive polymorphism, rs6887695, in a larger combined sample that included 578 patients and 1422 controls.
|
20875477 |
2010 |
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rs6887695
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Psoriasis
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0.100 |
GeneticVariation
|
BEFREE |
One of the IL12B markers, rs3212227, showed significant association with psoriasis (OR = 1.64, P = 0.0058) while the other, rs6887695, did not (OR = 1.29, P = 0.12).
|
19705136 |
2010 |
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rs6887695
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Psoriasis
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0.100 |
GeneticVariation
|
BEFREE |
Both IL12B markers showed highly significant association with psoriasis in the case-control (rs3212227, odds ratio (OR)=1.62, P=1.7 x 10(-15); rs6887695, OR=1.49, P=2.7 x 10(-15)) and in the family-based analysis (rs3212227, P=2.2 x 10(-3); rs6887695, P=1.7 x 10(-3)).
|
18219280 |
2008 |
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rs6887695
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Psoriasis
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0.100 |
GeneticVariation
|
BEFREE |
We replicated the previously reported association with interleukin 23 receptor and interleukin 12B (IL12B) polymorphisms in PS and PSA cohorts (IL23R: rs11209026, U.S. PS, P = 1.4x10(-4); U.K. PSA: P = 8.0x10(-4); IL12B:rs6887695, U.S. PS, P = 5x10(-5) and U.K. PSA, P = 1.3x10(-3)) and detected an independent association in the IL23R region with a SNP 4 kb upstream from IL12RB2 (P = 0.001).
|
18369459 |
2008 |
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rs6887695
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Psoriasis
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0.100 |
GeneticVariation
|
BEFREE |
Haplotypes were estimated, and genotype-conditioned analyses identified a second risk allele (rs6887695) located approximately 60 kb upstream of the IL12B coding region that exhibited association with psoriasis after adjustment for rs3212227.
|
17236132 |
2007 |
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rs6887695
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Arthritis, Psoriatic
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|
0.050 |
GeneticVariation
|
BEFREE |
The association to PsA was observed in the presence of polymorphisms: TNF-238 G > A (rs361525), -308 G > A (rs1800629), and -857 C > T (rs1799724); IL12B C > G (rs6887695) and A > C (rs3212227); IL23A A > G (rs2066808) and IL23R G > A (rs11209026).
|
30584776 |
2019 |
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rs6887695
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Arthritis, Psoriatic
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|
0.050 |
GeneticVariation
|
BEFREE |
After correction for multiple testing with a false discovery rate of 5%, two SNPs remained significant: TNF (rs361525) was associated with PsO, PsC10, and PsA; and IL12B (rs6887695) was associated with PsO.
|
29389950 |
2018 |
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rs6887695
|
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Arthritis, Psoriatic
|
|
0.050 |
GeneticVariation
|
BEFREE |
Then, for rs6887695, the pooled ORs were 0.704 (95 % CI 0.670-0.739) for psoriasis and 0.677 (95 % CI 0.599-0.767) for PsA.
|
23297015 |
2013 |
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rs6887695
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Arthritis, Psoriatic
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|
0.050 |
GeneticVariation
|
BEFREE |
For both PA and PV, we detected the strongest association with two IL12B single-nucleotide polymorphisms and the corresponding haplotype as reflected by minimal P-values of 10(-7) and highest odds ratios of 1.50 (1.28-1.75) for rs6887695 in PA patients and 1.50 (1.27-1.76) for rs3212227 in the PV cohort, respectively.
|
18800148 |
2009 |
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rs6887695
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Arthritis, Psoriatic
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|
0.050 |
GeneticVariation
|
BEFREE |
Both IL12B SNPs were independently associated with PsA susceptibility, and this association was strongest under a dominant model, with homozygosity for the common allele being more frequent in patients with PsA than in control subjects: for rs3212227, the odds ratio (OR) for carriage of AA versus other genotypes was 1.43 (95% confidence interval [95% CI] 1.17-1.76); for rs6887695, the OR for carriage of GG versus other genotypes was 1.43 (95% CI 1.18-1.74).
|
19035472 |
2008 |
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rs6887695
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Crohn Disease
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|
0.040 |
GeneticVariation
|
BEFREE |
Our genetic association study revealed that the polymorphisms of IL12B rs6887695 were associated with both CD and ulcerative colitis (UC) susceptibility in Chinese population, but did not affect the serum IL12p40 level in either CD patients or UC patients.
|
25761185 |
2015 |
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rs6887695
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Crohn Disease
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0.040 |
GeneticVariation
|
BEFREE |
The polymorphisms TLR5 (rs5744174) and IL12B (rs6887695) were associated with risk of CD, and TLR1 (rs4833095) and IL18 (rs187238) were associated with risk of both CD and UC (p<0.05).
|
26698117 |
2015 |
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rs6887695
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Crohn Disease
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|
0.040 |
GeneticVariation
|
BEFREE |
Our analysis revealed an association of the IL12B SNP rs6887695 with susceptibility to IBD (p = 0.035; OR 1.15 [95% CI 1.01-1.31] including a trend for rs6887695 for association with CD (OR 1.41; [0.99-1.31], p = 0.066) and UC (OR 1.18 [0.97-1.43], p = 0.092).
|
22479607 |
2012 |
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rs6887695
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Crohn Disease
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|
0.040 |
GeneticVariation
|
BEFREE |
Further genotype-phenotype analysis found a significant association between rs6887695 and patients with pure ileal CD.
|
18936107 |
2009 |
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rs6887695
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Rheumatoid Arthritis
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|
0.030 |
GeneticVariation
|
BEFREE |
The pooled results demonstrated that IL-12B rs3212227 (homozygote model: OR = 0.96, 95 % CI = 0.81-1.15; heterozygote model: OR = 1.07, 95 % CI = 0.93-1.23; dominant model: OR = 1.05, 95 % CI = 0.91-1.20; recessive model: OR = 0.93, 95 % CI = 0.79-1.10) and rs6887695 (homozygote model: OR = 1.01, 95 % CI = 0.84-1.21; heterozygote model: OR = 1.14, 95 % CI = 0.86-1.51; dominant model: OR = 1.14, 95 % CI = 0.87-1.48; recessive model: OR = 1.01, 95 % CI = 0.85-1.21) polymorphisms may not be associated with RA risk.
|
27312970 |
2017 |
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rs6887695
|
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Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, rs6887695 was associated with RA in Asian patients.
|
27155343 |
2016 |
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rs6887695
|
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Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Individuals carrying the rs3212227/rs6887695 C/C haplotype were associated with a significantly increased risk of RA.
|
25469793 |
2015 |