rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
rs3851179 and rs541458 appear to be associated with decreased AD risk.
|
31385771 |
2019 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our meta-analysis thus suggested that the PICALM rs3851179 polymorphism was associated with AD;</span> the APOE ε4 status did not influence the relationship.
|
30039188 |
2018 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The PICALM rs3851179 A allele is thought to have a protective effect, whereas the G allele appears to confer risk for AD.
|
28073596 |
2017 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The sensitivity analysis indicates that the association between rs3851179 and AD did </span>not vary substantially.
|
27048444 |
2017 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
There was no association observed with AD at both rs11136000 CLU (p=0.25) and rs3851179 PICALM (p=0.54).
|
28558900 |
2017 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Phosphatidylinositol-binding clathrin assembly protein (PICALM) (rs3851179) has been associated with AD; in particular, the A allele may serve a protective role, while the G allele serves as a strong genetic risk factor.
|
28549650 |
2017 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Re: "PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population".
|
26972434 |
2016 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The allele T of rs38</span>51179 in PICALM was associated with a 13 % increase in the risk of AD.
|
26611835 |
2016 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association between rs3851179 (PICALM), rs744373 (BIN1), and AD was further confirmed by meta-analysis of Asian populations.
|
25452228 |
2016 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
PICALM rs3851179 and CLU rs11136000 have been recently associated with Alzheimer's disease (AD).
|
24578178 |
2015 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We detected a significant association of the MTHFR rs1801133 and PICALM rs3851179 polymorphisms with AD.
|
25359311 |
2015 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Conditional on rs3851179, rs588076 was not associated with AD risk, suggesting that D18-19 PICALM is not critical in AD.
|
25169757 |
2014 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Here, we evaluated the association between the AD-associated polymorphism rs3851179 near PICALM, which encodes a clathrin-coated pit accessory protein.
|
24618820 |
2014 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
(2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI = 4.03 × 10(-05), pBMI corr = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI = 0.002, rs2075650 at TOMM40/APOE, pBMI = 0.024, rs3865444 at CD33, pBMI = 0.024).
|
24788522 |
2014 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We investigated the influence of the rs6656401 single nucleotide polymorphisms (SNP) of the CR1 gene, the rs3851179 SNP of the PICALM gene, and the rs11136000 SNP of the CLU gene on risk of AD in a Polish population.
|
23650005 |
2013 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results indicate that rs3851179 polymorphism is significantly associated with AD in the Asian population by both pooled analysis and meta-analysis methods.
|
23572399 |
2013 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We failed to replicate this association between the rs3851179 polymorphism and AD in all samples and the APOEε4-negative subgroup.
|
23040034 |
2013 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Gene-brain structure associations of 3 recently discovered risk genes for Alzheimer's disease, CLU (rs11136000C>T), CR1 (rs6656401G>A), and PICALM (rs3851179G>A), were investigated in 2 independent cohorts of young healthy adults (n = 430 and n = 492, respectively).
|
21726919 |
2011 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent genome-wide study (GWAS) identified a single nucleotide polymorphism (SNP) rs3851179 in the 5' to the PICALM gene strongly associated with Alzheimer's disease (AD) in Caucasians.
|
20951388 |
2011 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Unadjusted, CLU (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.85-0.96 for single-nucleotide polymorphism [SNP] rs11136000), CR1 (OR, 1.14; 95% CI, 1.07-1.22; SNP rs3818361), and PICALM (OR, 0.89; 95% CI, 0.84-0.94, SNP rs3851179) were associated with AD in white individuals.
|
20697030 |
2010 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86).
|
19734902 |
2009 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86).
|
19734902 |
2009 |
rs3851179
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86).
|
19734902 |
2009 |