|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results support the existence of a significant association between GSTP1 rs1695 and IL13 rs20541 SNPs, with susceptibility to asthma, in the population studied.
|
27561723 |
2018 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Children carrying GSTP1 rs1138272 or rs1695 minor alleles may constitute a susceptible population at increased risk of asthma associated with air pollution.
|
24465030 |
2014 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The glutathione S-transferase P1 Ile105Val polymorphism markedly modifies allergen-provoked airway inflammation in atopic asthmatics in vivo.
|
23600543 |
2013 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To assess the effect of IL13 (-1112 C>T and Arg110Gln), GSTP1 (Ile105Val), and CYP1A1 (Ile462Val) on asthma risk and ETS exposure, we recruited 201 unrelated children and classified them into four groups: (1) control without ETS exposure; (2) control with ETS exposure; (3) with asthma and with ETS exposure and (4) with asthma and without ETS exposure.
|
22236719 |
2012 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the role of polymorphisms in GSTP1 (Ile105Val and Ala114Val), alone and in combination with ETS exposure, on atopy and asthma severity.
|
20858151 |
2010 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis of GSTP1 Ile105Val (n = 17) and asthma suggested a possible protective effect of the Val allele, but heterogeneity was extreme.
|
20032267 |
2010 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The risk of asthma was lower for those with the Val allele of Ile105Val</span> (hazard ratio (HR) 0.60, 95% CI 0.4 to 0.8) and higher for the variant allele of rs6591255 (HR 1.40, 95% CI 1.1 to 1.9).
|
18988661 |
2009 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
If confirmed by independent studies, our results suggest that GSTP1 Ile105Val genotype strongly determines the progression of BHR to physician-diagnosed asthma in the general population.
|
18057098 |
2008 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Ile105Val allele and a SNP in the upstream promoter region (SNP1: rs6591255, putative transcription factor 1 binding site) were associated with asthma and wheezing outcomes, an association observed in two cohorts of the CHS recruited in different years.
|
18335111 |
2008 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The effect of GSTM1 null/present genotype on the association between GSTP1 Ile105Val and asthma was also investigated.
|
17643058 |
2007 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
High EPHX1 activity was associated with an increased risk for lifetime asthma (OR 1.51, 95% CI 1.14 to 1.98) which varied by GSTP1 Ile105Val genotype and by residential proximity to major roads (p for interaction = 0.006 and 0.03, respectively).
|
17711870 |
2007 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Children with asthma with val/val genotype at GSTP1 ile105val locus may be good candidates for supplemental antioxidant therapy.
|
17088135 |
2006 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped Ile105Val and Ala114Val in the Multicenter Allergy Study cohort (85 children with asthma, 123 controls) and asthmatic children from Freiburg (n = 178).
|
16176403 |
2005 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
GSTP1 Ile105Val polymorphism was determined using a single based extension method in 88 AIA subjects and compared to 154 aspirin-tolerant asthma (ATA) subjects and 119 normal healthy controls (NC) recruited from the Korean population.
|
16295782 |
2005 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism c.342A>G (p.I105V) in GSTP1 has previously been suggested as a risk factor for asthma.
|
15300848 |
2004 |
|
rs1695
|
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest a significant association between GSTP1 Ile105Val polymorphism and susceptibility to asthma and that the GSTP1 Val105Val genotype may be protective against developing this disease.
|
14748821 |
2004 |