|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
For MTHFD1 rs2236225 polymorphism, mothers having GA genotype and A allele exhibited an increased risk of NTDs in the offspring (OR = 2.600, 95%CI: 1.227-5.529; OR = 1.847, 95%CI: 1.047-3.259).
|
30867013 |
2019 |
|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
For rs2236225 within MTHFD1, children with allele A or genotype AA had a high NTDs risk (OR=1.500, 95%CI=1.061~2.120; OR=2.862, 95%CI=1.022~8.015, respectively).
|
29392422 |
2018 |
|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our research provides the first evidence supporting a paternal, rather than a maternal, transmission bias of MTHFD1 G1958A variant for NTD susceptibility in the offspring.
|
26394717 |
2016 |
|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
The haplotype GGGG, which consists of 4 SNPs (rs2236225, rs2236224, rs1256146, and rs6573559), is also associated with risk of NTDs (P value=0.0438, OR=0.7180, 95% CI=0.5214-0.9888).
|
26343515 |
2015 |
|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, there was no significant association between the MTHFD1 G1958A polymorphism in NTD patients and the risk of NTD.
|
25502174 |
2015 |
|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our analysis implicated that MTHFD1 1958G>A was significantly associated with the susceptibility of NTD in a Chinese population.
|
25524527 |
2015 |
|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, our meta-analysis strongly suggests that the MTHFD1 G1958A polymorphism might be associated with maternal risk for NTDs in Caucasian populations.
|
24977710 |
2014 |
|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFD1 p.R653Q has been proposed as a risk factor for neural tube defects (NTDs), congenital heart defects (CHDs) and pregnancy losses.
|
23704330 |
2013 |
|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ten strongest association signals (p-value range: 0.0003-0.0023) were found in nine genes (MFTC, CDKN2A, ADA, PEMT, CUBN, GART, DNMT3A, MTHFD1 and T (Brachyury)) and included the known NTD risk factor MTHFD1 R653Q (rs2236225).
|
22856873 |
2012 |
|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ten strongest association signals (p-value range: 0.0003-0.0023) were found in nine genes (MFTC, CDKN2A, ADA, PEMT, CUBN, GART, DNMT3A, MTHFD1 and T (Brachyury)) and included the known NTD risk factor MTHFD1 R653Q (rs2236225).
|
22856873 |
2012 |
|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated this SNP as a potential risk factor for NTDs in a large homogenous Irish population and determined that it is not an independent risk factor, but, it does increase both case (chi (2) = 11.06, P = 0.001) and maternal (chi (2) = 6.68, P = 0.01) risk when allele frequencies were analysed in combination with the previously identified disease-associated p.R653Q (c.1958 G > A; dbSNP rs2236225) polymorphism.
|
19130090 |
2009 |
|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common variant in MTHFD1, p.Arg653Gln (c.1958G>A), may increase the risk for neural tube defects (NTD).
|
18767138 |
2009 |
|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common variant in MTHFD1, p.Arg653Gln (c.1958G>A), may increase the risk for neural tube defects (NTD).
|
18767138 |
2009 |
|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, our results indicate that heterozygosity and homozygosity for the MTHFD1 1958G > A polymorphism are genetic determinants of NTD risk in the cases examined.
|
16315005 |
2006 |
|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have established that the MTHFD1 1958G>A polymorphism has a significant role in influencing a mother's risk of having an NTD-affected pregnancy in the Irish population.
|
16552426 |
2006 |
|
rs2236225
|
|
Neural Tube Defects
|
|
0.100 |
GeneticVariation
|
BEFREE |
One SNP, R653Q, in this gene appears to be associated with NTD risk.
|
12384833 |
2002 |