|
rs2391191
|
|
Schizophrenia
|
|
0.090 |
GeneticVariation
|
BEFREE |
On the one hand, the SNP rs2391191 corresponding to the R30K substitution in pLG72 was genetically linked to schizophrenia, reduced thickness of the brain cortex in schizophrenia-affected individuals, and altered memory function.
|
29417050 |
2018 |
|
rs2391191
|
|
Schizophrenia
|
|
0.090 |
GeneticVariation
|
BEFREE |
The stage-1 study showed association of the DAOA and PSEN2 genes with schizophrenia in a small sample; the stage-2 study with an expanded sample confirmed the disease association for 2-SNP and 3-SNP haplotypes, and the cis-phase interactions between rs2391191 and some other SNPs in the DAOA gene.
|
23335491 |
2013 |
|
rs2391191
|
|
Schizophrenia
|
|
0.090 |
GeneticVariation
|
BEFREE |
No significant effect was observed in healthy controls.The finding of our study that the Arg30Lys risk variant is associated with a distinct cortical thinning provides new evidence for the pathophysiological impact of DAOA in schizophrenia.
|
21508934 |
2011 |
|
rs2391191
|
|
Schizophrenia
|
|
0.090 |
GeneticVariation
|
BEFREE |
Marker rs1935062 may be specifically associated with BD, while marker rs2391191 may be associated with SZ but not with BD.
|
21443574 |
2011 |
|
rs2391191
|
|
Schizophrenia
|
|
0.090 |
GeneticVariation
|
BEFREE |
We also found nominal haplotypic association, including M15/rs2391191 and M19/rs778294 with schizophrenia.
|
19237267 |
2009 |
|
rs2391191
|
|
Schizophrenia
|
|
0.090 |
GeneticVariation
|
BEFREE |
For each gene, we genotyped 213 cases and 197 controls for SNPs previously associated with schizophrenia: rs2111902 (MDAAO-4), rs3918346 (MDAAO-5), rs3741775 (MDAAO-6) and rs3918347 (MDAAO-7) in DAO and rs746187 (M7), rs3916966 (M13), rs2391191 (M15) and rs3916972 (M25) in G72.
|
18165970 |
2008 |
|
rs2391191
|
|
Schizophrenia
|
|
0.090 |
GeneticVariation
|
BEFREE |
In order to evaluate the potential association of these two genes with schizophrenia in a Taiwanese sample, three single nucleotide polymorphisms (SNPs) for DAAO (rs2111902, rs3918346, rs3741775) and eleven SNPs for G72 (rs3916965, rs3916966, rs3916967, rs2391191, rs3916968, rs947267, rs778294, rs3916970, rs3916971, rs778293, rs3918342) were genotyped by the MALDI-TOF mass spectrometry method in 218 families (864 individuals) containing at least two siblings affected with schizophrenia.
|
16842973 |
2006 |
|
rs2391191
|
|
Schizophrenia
|
|
0.090 |
GeneticVariation
|
BEFREE |
Significant associations of schizophrenia with the A allele of rs947267 (P=0.012) and haplotype A-A-G (rs2391191-rs947267-rs778294) (P=0.008) were found in early-onset schizophrenic patients.
|
17179866 |
2006 |
|
rs2391191
|
|
Schizophrenia
|
|
0.090 |
GeneticVariation
|
BEFREE |
In this work, we have identified statistically significant differences in allele distributions of two markers rs3916965 (P = 0.019) and rs2391191 (P = 0.0010), and a highly significant association between haplotype AGAC of the G72/G30 locus (P = 1.7 x 10(-4)) and schizophrenia.
|
15194506 |
2004 |