|
rs10069690
|
|
Breast Carcinoma
|
|
0.750 |
GeneticVariation
|
BEFREE |
The variants rs10069690 and rs2853676 were also described as risk factors for BC.
|
29332343 |
2019 |
|
rs10069690
|
|
Breast Carcinoma
|
T |
0.750 |
GeneticVariation
|
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs10069690
|
|
Breast Carcinoma
|
T |
0.750 |
GeneticVariation
|
GWASCAT |
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.
|
29058716 |
2017 |
|
rs10069690
|
|
Breast Carcinoma
|
|
0.750 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that TERT rs2736109, rs2853669, rs2736098, and rs10069690 polymorphisms were associated with increased risk of developing breast cancer.
|
27461695 |
2017 |
|
rs10069690
|
|
Breast Carcinoma
|
|
0.750 |
GeneticVariation
|
BEFREE |
Different genotypes of rs3803662 (TOX3)/ (TNRC9)) in the case group and the control group are statistically significant (P = 0.044), but the ones of rs10069690 (TERT), rs2046210 (6q25.1), rs2981582 (EGFR2), and rs889312 (MAP3K1) have no significant statistical differences with breast cancer (P = 0.772, 0.308, 0.376, 0.468).
|
26803517 |
2016 |
|
rs10069690
|
|
Breast Carcinoma
|
T |
0.750 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
|
rs10069690
|
|
Breast Carcinoma
|
T |
0.750 |
GeneticVariation
|
GWASCAT |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
|
rs10069690
|
|
Breast Carcinoma
|
|
0.750 |
GeneticVariation
|
BEFREE |
Several TL-related single nucleotide polymorphisms had modest association with breast cancer risk overall, including TEP1 rs93886 (OR 0.82, 95% CI 0.70,0.95); TERF2 rs3785074 (OR 1.13, 95% CI 1.03,1.24); TERT rs4246742 (OR 0.85, 95% CI 0.77,0.93); TERT rs10069690 (OR 1.13, 95% CI 1.03,1.24); TERT rs2242652 (OR 1.51, 95% CI 1.11,2.04); and TNKS rs6990300 (OR 0.89, 95% CI 0.81,0.97).
|
23629941 |
2013 |
|
rs10069690
|
|
Breast Carcinoma
|
T |
0.750 |
GeneticVariation
|
GWASCAT |
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
|
23535733 |
2013 |
|
rs10069690
|
|
Breast Carcinoma
|
|
0.750 |
GeneticVariation
|
BEFREE |
Seven SNPs were statistically significant (P ≤ 0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/TERT), rs999737 (14q24/RAD51L1), rs13387042 (2q35/TNP1), rs1219648 (10q26/FGFR2), rs8170 (19p13/BABAM1), rs17817449 (16q12/FTO), and rs13329835 (16q23/DYL2).
|
23593120 |
2013 |
|
rs10069690
|
|
Breast Carcinoma
|
T |
0.750 |
GeneticVariation
|
GWASCAT |
We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 × 10(-10)).
|
22037553 |
2011 |
|
rs2853669
|
|
Breast Carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
In this study, it was found that there was no statistical difference between hTERT rs2736109 G>A, rs2735940 T>C, rs2853669 A>G, rs2736098 G>A, and rs2736100 T>G polymorphisms that can be associated with risk of BC.
|
29506639 |
2018 |
|
rs2853669
|
|
Breast Carcinoma
|
G |
0.740 |
GeneticVariation
|
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs2853669
|
|
Breast Carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
We also found rs2853669 and rs2736098 polymorphisms were significantly associated with breast cancer risk (OR = 0.76; 95% CI: 0.63-0.90; P = 0.002 and OR = 0.79; 95% CI: 0.72-0.87; P < 0.00001), respectively.
|
27461695 |
2017 |
|
rs2853669
|
|
Breast Carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
Collectively, our functional studies of the <i>TERT</i>-<i>CLPTM1L</i> breast cancer susceptibility locus describe rs2853669 as a functional variant of this association signal among three other potentially causal variants and demonstrate the versatile mechanisms by which <i>TERT</i> promoter variants may affect breast cancer risk.
|
28978027 |
2017 |
|
rs2853669
|
|
Breast Carcinoma
|
|
0.740 |
GeneticVariation
|
BEFREE |
It was observed that hTERT rs2736098 was associated with breast cancer risk (odds ratio [OR] = 1.88; p = 0.034), while rs2736100 and rs2853669 did not significantly differ between the groups.
|
27336831 |
2016 |
|
rs2242652
|
|
Breast Carcinoma
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.
|
27117709 |
2016 |
|
rs2242652
|
|
Breast Carcinoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
Several TL-related single nucleotide polymorphisms had modest association with breast cancer risk overall, including TEP1 rs93886 (OR 0.82, 95% CI 0.70,0.95); TERF2 rs3785074 (OR 1.13, 95% CI 1.03,1.24); TERT rs4246742 (OR 0.85, 95% CI 0.77,0.93); TERT rs10069690 (OR 1.13, 95% CI 1.03,1.24); TERT rs2242652 (OR 1.51, 95% CI 1.11,2.04); and TNKS rs6990300 (OR 0.89, 95% CI 0.81,0.97).
|
23629941 |
2013 |
|
rs7726159
|
|
Breast Carcinoma
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.
|
27117709 |
2016 |
|
rs7726159
|
|
Breast Carcinoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate the association of allelic variants of three functional polymorphisms rs2853669, rs2736100, and rs7726159 in the telomerase reverse transcriptase (TERT) gene with the risk of the breast cancer and prostate cancer in Russian population.
|
25296732 |
2015 |
|
rs3215401
|
|
Breast Carcinoma
|
A |
0.700 |
GeneticVariation
|
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs3215401
|
|
Breast Carcinoma
|
A |
0.700 |
GeneticVariation
|
GWASCAT |
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.
|
29058716 |
2017 |
|
rs7725218
|
|
Breast Carcinoma
|
A |
0.700 |
GeneticVariation
|
GWASCAT |
Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
|
27197191 |
2016 |
|
rs2736098
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In this study, it was found that there was no statistical difference between hTERT rs2736109 G>A, rs2735940 T>C, rs2853669 A>G, rs2736098 G>A, and rs2736100 T>G polymorphisms that can be associated with risk of BC.
|
29506639 |
2018 |
|
rs2736098
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
We also found rs2853669 and rs2736098 polymorphisms were significantly associated with breast cancer risk (OR = 0.76; 95% CI: 0.63-0.90; P = 0.002 and OR = 0.79; 95% CI: 0.72-0.87; P < 0.00001), respectively.
|
27461695 |
2017 |