|
rs4938723
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
CONCLUSIONS Current meta-analysis suggested that rs4938723 polymorphism was potentially associated with hepatocellular carcinoma risk, but this polymorphism had a decreased association for susceptibility to esophageal cancer, leukemia, and colorectal cancer.
|
30286050 |
2018 |
|
rs4938723
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, hsa-<i>mir-146a</i> rs2910164 and hsa-<i>mir-34b/c</i> rs4938723 could be biomarkers for the HCC risk while hsa-<i>mir-196a-2</i> rs11614913 and hsa-<i>mir-149</i> rs2292832 had potential to be biomarkers for HBV-related HCC risk.
|
29976775 |
2018 |
|
rs4938723
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, several studies have investigated the association between polymorphisms in miR-146a rs2910164, miR-196a2 rs11614913, miR-499 rs3746444, miR-149 rs229283, miR-34b/c rs4938723, and hepatocellular carcinoma (HCC), which showed inconclusive results.
|
28188097 |
2017 |
|
rs4938723
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Using a stratified subgroup analysis, rs4938723 polymorphisms were associated with an increased risk for hepatocellular carcinoma, but decreased risk for colorectal, gastric, and esophageal squamous cell cancer.
|
28415817 |
2017 |
|
rs4938723
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TC (adjusted OR = 1.46, 95%CI = 1.06-2.01) and CC (adjusted OR = 3.07, 95%CI = 1.77-5.34) genotypes of pri-miR-34b/c rs4938723 were correlated with a higher risk of HCC compared to the TT genotype.
|
27808368 |
2016 |
|
rs4938723
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
After stratifying by ethnicity and cancer type, genotype CT of rs4938723 was significantly association with an increased cancer risk in Asian population (P(h)=0.187, OR=1.10, 95%CI=1.01-1.20), allele C and genotype CT were significantly positive associated with hepatocellular cancer (P(h)=0.113, OR=1.11, 95%CI=1.01-1.23 for C vs. T; P(h)=0.121, OR=1.19, 95%CI=1.03-1.37 for CT vs. TT), but rs4938723 was negative associated with risk of colorectal cancer (P(h)=0.342, OR=0.66, 95%CI=0.47-0.92 for CC vs. TT; P(h)=0.519, OR=0.67, 95%CI=0.49-0.93 for CC vs. CT/TT; P(h)=0.443, OR=0.71, 95%CI=0.51-0.99 for CC/TT vs. CT).
|
25475831 |
2015 |
|
rs4938723
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This rs4938723 SNP showed an opposite tendency orientation between the hepatocellular cancer and colorectal cancer risks.
|
25201061 |
2014 |
|
rs4938723
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The functional polymorphism rs4938723 in the promoter region of pri-miR-34b/c is potentially associated with susceptibility to several cancers, including hepatocellular carcinoma, colorectal cancer, and breast cancer.
|
25326793 |
2014 |
|
rs4938723
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that rs4938723 is not associated with the risk of HCC.
|
23935875 |
2013 |
|
rs4938723
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study aimed to assess whether polymorphisms in the single-nucleotide polymorphism miR-34b/c T>C (rs4938723) and TP53 Arg72Pro (rs1042522) increase the risk of HCC and influence outcome in patients with HCC.
|
23632240 |
2013 |
|
rs4938723
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
rs4938723 might be a genetic risk factor of HCC but its effect on HCC is significantly affected by the HBV mutations. rs11614913 might not be a HCC susceptible factor but it might affect the effects of the HBV mutations or rs4938723 on HCC risk.
|
23516510 |
2013 |
|
rs4938723
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings indicate that the potentially functional SNP r</span>s4938723 in the promoter region of pri-miR-34b/c may contribute to the susceptibility of HCC in this Chinese population.
|
20309940 |
2011 |