|
rs63750847
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease.
|
29807259 |
2018 |
|
rs63750847
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This effect closely mimics the phenotype of APP A673T, a recently discovered mutation that protects carriers against AD and age-related cognitive decline.
|
28115709 |
2017 |
|
rs63750847
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Decreased plasma β-amyloid in the Alzheimer's disease APP A673T variant carriers.
|
28556232 |
2017 |
|
rs63750847
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Sequencing of <i>APP</i> in familial early-onset AD identified missense mutations that cause AD, while a recently discovered coding variant, APP A673T, reduces the risk for AD.
|
28003277 |
2017 |
|
rs63750847
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, because of the extreme rarity of A673T in non-Nordic populations, the association with Alzheimer's disease has not yet been formally replicated.
|
26239177 |
2015 |
|
rs63750847
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
|
25531812 |
2015 |
|
rs63750847
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A rare amyloid precursor protein gene variant, A673T (rs63750847) was recently reported to protect against Alzheimer's disease and age-related cognitive decline among Icelanders and the same rare variant was observed also in Finnish, Norwegian, and Swedish populations.
|
24529499 |
2014 |
|
rs63750847
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The A598T mutation of amyloid precursor protein APP is linked to a reduction in the incidence rate of Alzheimer's disease (AD).
|
24646423 |
2014 |
|
rs63750847
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Given the previous observation from Asians, our results suggest that the A673T variant is not involved in longevity in Chinese individuals; some other protective mechanisms may contribute to a lower incidence of AD in Chinese nonagenerians and centenarians.
|
24126161 |
2014 |
|
rs63750847
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease and other neurological diseases.
|
23652020 |
2013 |
|
rs63750847
|
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, as the A673T allele also protects against cognitive decline in the elderly without Alzheimer's disease, the two may be mediated through the same or similar mechanisms.
|
22801501 |
2012 |