Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2228145
rs2228145
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.850 GeneticVariation BEFREE The recent meta-analysis of GWAS has expanded the total number of RA-associated loci to more than 100, out of which approximately ∼97% (98 variants) loci are located in non-coding regions, and the other ∼3% (3 variants) are in three different non-HLA genes, i.e., TYK2 (Prp1104Ala), IL6R (Asp358Ala), and PTPN22 (Trp620Arg). 30899276

2019

dbSNP: rs2228145
rs2228145
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.850 GeneticVariation BEFREE Interleukin-6-receptor polymorphisms rs12083537, rs2228145, and rs4329505 as predictors of response to tocilizumab in rheumatoid arthritis. 24978393

2014

dbSNP: rs2228145
rs2228145
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.850 GeneticVariation BEFREE Although a common, non-synonymous variant in the IL-6 receptor gene (IL6R Asp358Ala; rs2228145 A>C) is associated with the risk of several common diseases, with the 358Ala allele conferring protection from coronary heart disease (CHD), rheumatoid arthritis (RA), atrial fibrillation (AF), abdominal aortic aneurysm (AAA), and increased susceptibility to asthma, the variant's effect on IL-6 signaling is not known. 23593036

2013

dbSNP: rs2228145
rs2228145
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.850 GeneticVariation BEFREE In conclusion, our results do not confirm an association of IL6R rs2228145 and IL6ST/gp130 rs2228044 polymorphisms with CV disease in RA. 21981268

2011

dbSNP: rs2228145
rs2228145
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.850 GeneticVariation BEFREE An association between disease status and the sIL-6R rs8192284 (A358D) variant was tested in 965 patients with RA and 988 unrelated healthy controls. 19713205

2010