|
rs1217691063
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Subjects with diabetes had significantly higher homocysteine (Hcy) levels than the control subjects; however, there was no statistical difference in plasma Hcy values between carriers of mutant genotypes (CT/TT for C677T and AC/CC for A1298C) and wild types (CC and AA) in patients with diabetes.
|
28341195 |
2017 |
|
rs1217691063
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, a significantly elevated risk of DN was associated with all variants of MTHFR C677T when compared with the healthy group (T vs C, odds ratio (OR) = 2.22, 95% confidence interval (CI) = 1.88-2.61; TT vs CC, OR = 4.22, 95% CI = 3.02-5.90; TT + CT vs CC, OR = 2.62, 95% CI = 2.07-3.31; TT vs CC + CT, OR = 2.81, 95% CI = 2.08-3.81) or DM (T vs C, OR = 1.78, 95% CI = 1.59-2.00; TT vs CC, OR = 2.95, 95% CI = 2.33-3.73; TT + CT vs CC, OR = 1.93, 95% CI = 1.63-2.29; TT vs CC + CT, OR = 2.31, 95% CI = 1.87-2.84).
|
26072975 |
2016 |
|
rs1217691063
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study is to quantify global DNA methylation and investigate the relationship with diabetes status and polymorphisms in MTHFR C677T and NOS3 G894T genes in mixed ancestry subjects from South Africa.
|
27990443 |
2016 |
|
rs1217691063
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Relationship of MTHFR gene 677C → T polymorphism, homocysteine, and estimated glomerular filtration rate levels with the risk of new-onset diabetes.
|
25700330 |
2015 |
|
rs1217691063
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with various diseases (vascular, cancers, neurology, diabetes, psoriasis, etc) with the epidemiology of the polymorphism of the C677T that varies dependent on the geography and ethnicity.
|
25449138 |
2015 |
|
rs1217691063
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the present study was to evaluate the effect of simvastatin treatment on circulating Hcy levels in obese women without hypertension, diabetes or dyslipidaemia; and to determine whether the 677C>T polymorphism located in methylenetetrahydrofolate reductase (NAD(P)H) (MTHFR) gene modulates the effects of this treatment on Hcy and nitrite (as a biomarker of nitric oxide (NO) bioavailability).
|
25115547 |
2014 |
|
rs1217691063
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current meta-analysis suggested that MTHFR C677T polymorphism might influence DN risk, but not for DM in the Chinese population.
|
23822721 |
2013 |
|
rs1217691063
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
A comprehensive literature search was conducted to collect data from all case-control observational studies that investigated association of C677T polymorphism in MTHFR gene with DM or DN in a Chinese population.
|
22209973 |
2012 |
|
rs1217691063
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Individuals with a family history of diabetes or with risk factors such as obesity, hypertension, and impaired glucose tolerance should be screened for MTHFR C677T mutation and may be prescribed folic acid, vitamin B6, and vitamin B12 to assess if this helps in delaying the onset of diabetes.
|
21186995 |
2011 |
|
rs1217691063
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the association between MTHFR gene C677T polymorphism in diabetes and obesity with serum homocysteine levels.
|
19437140 |
2010 |
|
rs1217691063
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggest that ACE ID polymorphism may act synergistically with MTHFR C677T polymorphism to assess diabetes risk.
|
19857476 |
2010 |
|
rs1217691063
|
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between plasma Hcy and serum IL-6 levels supports the hypothesis that the activation of innate immunity is involved in the pathogenesis of arteriosclerosis in patients with diabetes mellitus who are homozygous for the TT genotype of C677T MTHFR.
|
15931619 |
2005 |