rs121913502
|
|
Leukemia, Myelocytic, Acute
|
|
0.780 |
GeneticVariation
|
BEFREE |
Genome-wide co-expression network analysis identified several IDH2 R140Q</span> co</span>-expressed genes, of which</span> 56 were significantly associated with AML OS.
|
30896832 |
2019 |
rs121913502
|
|
Leukemia, Myelocytic, Acute
|
|
0.780 |
GeneticVariation
|
BEFREE |
Using the IDH2 R140Q mutation as a model, we present a new effective methodology here using the RNA-guided clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system to reproduce or remove AML-associated mutations in or from human leukemic cells, respectively, via introduction of a DNA template at the endogenous gene locus via homologous recombination.
|
28325290 |
2017 |
rs121913502
|
|
Leukemia, Myelocytic, Acute
|
|
0.780 |
GeneticVariation
|
BEFREE |
To determine whether mutant IDH enzymes are valid targets for cancer therapy, we created a mouse model of AML in which mice were transplanted with nucleophosmin1 (NPM)(+/-) hematopoietic stem/progenitor cells cotransduced with four mutant genes (NPMc, IDH2/R140Q, DNMT3A/R882H, and FLT3/ITD), which often occur simultaneously in human AML patients.
|
25795706 |
2015 |
rs121913502
|
|
Leukemia, Myelocytic, Acute
|
|
0.780 |
GeneticVariation
|
BEFREE |
Of 230 samples from patients with AML 30 (13%) samples had DNMT3A mutations, 16 (7%) samples had IDH2 R140Q mutations and 36 (16%) samples had IDH1 mutations.
|
24887327 |
2014 |
rs121913502
|
|
Leukemia, Myelocytic, Acute
|
|
0.780 |
GeneticVariation
|
BEFREE |
Rapid detection of IDH2 (R140Q and R172K) mutations in acute myeloid leukemia.
|
23949315 |
2013 |
rs121913502
|
|
Leukemia, Myelocytic, Acute
|
|
0.780 |
GeneticVariation
|
BEFREE |
IDH mutations occurred at a considerable frequency of 15.89% in Chinese AML cases; IDH2 R140Q was the most frequent genetic alteration and was associated with older age, normal karyotype, and French-American-British classification M2 at diagnosis.
|
22494415 |
2012 |
rs121913502
|
|
Leukemia, Myelocytic, Acute
|
|
0.780 |
GeneticVariation
|
BEFREE |
Intriguingly, the IDH2 mutation p.R140Q and novel IDH1 mutation p.I99M co-occurred in a 75-year-old patient with AML developed from myelodysplastic syndromes (MDS).
|
20946881 |
2010 |
rs121913502
|
|
Leukemia, Myelocytic, Acute
|
|
0.780 |
GeneticVariation
|
BEFREE |
IDH2 mutations included R140Q (n=3; one post-PMF AML, one post-PV AML and one PMF) and a novel R140W (n=1; mutation found in both chronic- and blast-phase samples).
|
20410924 |
2010 |