Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799883
rs1799883
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation BEFREE We identified 5 studies for Ala54Thr association with obesity in Asian subjects. 26238699

2015

dbSNP: rs1799883
rs1799883
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation BEFREE The FABP2 Ala54Thr polymorphism was significantly associated with obesity (AT vs AA: OR = 2.633, 95%CI = 1.065-6.663, P = 0.036; TT vs AA: OR = 4.160, 95%CI = 1.609-10.757, P = 0.003) and metabolic syndrome (TT vs AA: OR = 2.273, 95%CI = 1.242-4.156, P = 0.008) by logistic regression with adjustment for covariates. 25730055

2015

dbSNP: rs1799883
rs1799883
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation BEFREE To analyze the effect of the fatty acid-binding protein (FABP2) gene Ala54Thr polymorphism on anthropometric and biochemical variables in response to a moderate-fat diet in overweight or obese subjects. 22817827

2013

dbSNP: rs1799883
rs1799883
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation BEFREE FABP2 A54T polymorphism may help identify Caucasian subjects at risk for obesity. 19324445

2009

dbSNP: rs1799883
rs1799883
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation BEFREE Influence of ALA54THR polymorphism of fatty acid-binding protein 2 on obesity and cardiovascular risk factors. 17992640

2007

dbSNP: rs1799883
rs1799883
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation BEFREE Preliminary evidence of FABP2 A54T polymorphism associated with reduced risk of type 2 diabetes and obesity in women from a German cohort. 16718632

2006

dbSNP: rs1799883
rs1799883
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation BEFREE The aim of this study was to assess the frequency of fatty acid binding protein 2 (FABP2) Ala54Thr genetic polymorphism and to evaluate its association with obesity and insulin resistance in Chilean aboriginal populations. 17211557

2006

dbSNP: rs1799883
rs1799883
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation BEFREE The Ala54Thr polymorphism was not associated with type 2 diabetes mellitus or obesity. 16919542

2006

dbSNP: rs1799883
rs1799883
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation BEFREE Our results suggest that the Ala54Thr polymorphism of the FABP2 gene is associated with obesity and insulin resistance. 14981227

2004

dbSNP: rs1799883
rs1799883
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation BEFREE Our data suggested that Ala54Thr polymorphism of the FABP2 gene is not a major contributing factor for obesity and obesity with dyslipidemia in Japanese children. 11866034

2001

dbSNP: rs1799883
rs1799883
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation BEFREE A missense mutation (A54T) in the fatty acid binding protein type 2 (FABP2) gene has been associated with insulin resistance and obesity. 11707533

2001

dbSNP: rs1799883
rs1799883
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation BEFREE (1) The Ala54 and Thr54 allele frequencies in Chinese were 0.71 and 0.29 respectively; (2) The FABP2-Ala54Thr variation was neither associated with fasting and post-challenged plasma glucose levels nor with NIDDM; (3) This variation was neither associated with fasting lipid profile nor with obesity; (4) The IGT subjects with genotype Thr54(+) (Thr54 homozygotes and heterozygotes) had lower fasting, 2-hour and total C-peptide levels and smaller AUC representing lesser C-peptide secretion after glucose challenge than those with genotype Thr54(-) (Ala54 homozygotes) (P = 0.04, 0.03, 0.01 and 0.01 respectively). 11593593

1999

dbSNP: rs1799883
rs1799883
CUI: C0028754
Disease: Obesity
Obesity
0.100 GeneticVariation BEFREE An alanine to threonine substitution at codon 54 of the fatty acid binding protein 2 (FABP2) gene has been associated with insulin resistance in Pima Indians and with obesity in aboriginal Canadians. 10337870

1999