|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the associations of two obesity-associated genes, FTO (rs9939609) and GNB3 (rs5443) single nucleotide polymorphisms (SNPs), with early pregnancy body mass index, gestational weight gain, and postpartum weight retention.
|
29469022 |
2018 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
GNB3 duplication is responsible for a syndromic form of childhood obesity, and an activating DNA sequence variant (C825T) in GNB3 is also associated with obesity.
|
29206867 |
2017 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphisms (SNPs) of the above genes, such as GNB3-C825T, ADRB3-Trp64Arg, UCP2-3'UTR 45 bp del/ins, and PPARγ-Pro12Ala, are associated with obesity and body mass index.
|
24827746 |
2014 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the associations between the GNB3 C825T polymorphism and obesity-related metabolic risk factors among Korean obese women.
|
25280441 |
2014 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C825T polymorphism of the gene encoding the human G protein beta-3 subunit (GNB3) is associated with hypertension and obesity.
|
25463071 |
2014 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the study was to examine the association between the G protein β3 subunit C825T polymorphism, associated with cardiovascular risk factors like hypertension (HT) and obesity and microalbuminuria (MA), reflecting the endothelial dysfunction in the atherosclerotic process.
|
20577224 |
2010 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene.
|
19687782 |
2009 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
It has been reported that C825T variant in the gene encoding the G-protein subunit beta3 (GNB3) is associated with antipsychotic-induced weight gain and obesity.
|
18793692 |
2008 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the variation within the GNB3 gene may interact with physical activity level to influence obesity status and, together with obesity and physical activity, the GNB3 825C>T variant may influence hypertension prevalence in AAs.
|
17299380 |
2007 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the C825T polymorphism influences lipid metabolism and is not associated with hypertension, obesity, insulin resistance, diabetes, diabetic complications, or diabetic therapies.
|
17161225 |
2007 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C825T variant of the G-protein beta3 subunit (GNB3) gene has attracted renewed attention as a candidate gene for obesity, hypertension and hyperuricemia.
|
16707857 |
2006 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In contrast, analyses in logistic regression models showed that the C825T polymorphism was not significantly associated with each of the four major classical risk factors for cardiovascular and cerebrovascular disease (obesity, hypertension, hypertriglyceridemia, and diabetes mellitus).
|
15033462 |
2004 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore our work does not provide evidence in favor of GNB3 C825T being a candidate gene for conferring genetic susceptibility to hypertension or obesity in northern Chinese population.
|
13679998 |
2003 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The GNB3 C825T gene polymorphism has recently been identified and associated with hypertension, obesity and left ventricular hypertrophy.
|
12566975 |
2003 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C825T polymorphism of the G-protein beta(3) subunit gene, known to be associated with obesity, is a determinant of weight gain during pregnancy.
|
12668921 |
2003 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied the C825T polymorphism in relation to blood pressure, obesity and intermediate phenotypes in a Caucasian population.
|
12658019 |
2003 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 825T-allele of the C825T polymorphism in GNB3, the gene for the G protein beta3 subunit, has been reported to be associated with essential hypertension and obesity.
|
12730030 |
2003 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C825T dimorphism of the gene encoding the human G protein beta3 subunit (GNB3) is associated with hypertension and obesity.
|
12624279 |
2003 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
A polymorphism (C825T) in the gene encoding the G protein beta3 subunit (GNB3) has recently been associated with hypertension and obesity in several populations.
|
12109775 |
2002 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
BP values in young male whites increased significantly with increasing BMI values but were independent of the C825T polymorphism, suggesting that hypertension associated with the 825T allele could be a consequence of obesity.
|
10477144 |
1999 |