|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study indicated a significantly closer association between COMT Val158Met polymorphism and PD in the Japanese and Indian populations compared with other ethnicities.
|
30644790 |
2019 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine whether dopaminergic (rs1076560 DRD2 G > T and rs4680 catechole-o-methyltranspherase (COMT) Val158Met) or brain derived neurotrophic factor (rs6265 BDNF Val66Met) genetic polymorphisms are associated with gait function and medication responsiveness in Parkinson's disease.
|
29249680 |
2018 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Cox proportional regression analysis adjusted for covariates revealed that among patients with PD, those carrying the high-COMT activity haplotype (G_C_C_G for rs6269, rs4633, rs4818, and rs4680) showed a high risk of cognitive decline (hazard ratio = 3.24; P = 0.02).
|
29439855 |
2018 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The frequencies of rs4633 T carriers, rs4680 A carriers and the two linked rs4633-rs4680 T/A carriers were significantly higher in the early onset PD group than in the healthy controls (all <i>P</i> < 0.05).
|
28451382 |
2017 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results demonstrate that COMT Val158Met polymorphism is probably not associated with increased risk of PD, but has an effect on prefrontal executive function interacting with gender and dopaminergic medication.
|
27653922 |
2016 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The COMT Val158Met polymorphism as an associated risk factor for Parkinson's disease in Asian rather than Caucasian populations.
|
23466833 |
2016 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Dopaminergic denervation severity depends on COMT Val158Met polymorphism in Parkinson's disease.
|
25753458 |
2015 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of COMT Val158Met polymorphism with wearing-off susceptibility in Parkinson's disease.
|
25367407 |
2015 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study showed that the Val158Met polymorphism of COMT gene may be associated with PD in Japanese rather than Chinese population.
|
25060648 |
2015 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Catechol-O-methyltransferase Val158Met polymorphism: modulation of wearing-off susceptibility in a Chinese cohort of Parkinson's disease.
|
25108642 |
2014 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Task-specific regional activations in Parkinson's disease were linked with genetic variation: the rs4680 polymorphism modulated the effect of levodopa therapy on planning-related activations in the frontoparietal network; the MAPT haplotype modulated parietal activations associated with spatial rotations; and APOE allelic variation influenced the magnitude of activation associated with memory encoding.
|
25080285 |
2014 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the relation between inhibitory ability (measured by the Stop Signal Task) and polymorphisms of COMT Val158Met and DRD2 C957T in patients with idiopathic PD.
|
24749760 |
2014 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of the meta-analysis suggest that the COMT rs4680 polymorphism is not a major determinant of either the risk for PD or clinical, neuropharmacological and neurochemical features of PD.
|
24819480 |
2014 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, the Val158Met COMT polymorphism is not associated with PD in the Caucasian population but acts as a modifier of the AAO in PD with a sexual dimorphism: the Val allele is associated with a younger AAO in men with idiopathic PD.
|
23408064 |
2013 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We sought to determine whether the COMT val158met polymorphism (rs4680) is associated with delusions and hallucinations in people with dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD).
|
23069674 |
2012 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, COMT: rs4680: A>G and rs4633: C>T polymorphisms were found to significantly affect PD risk, and the MTHFR 677C>T polymorphism helped determine plasma Hcy concentrations.
|
22890010 |
2012 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We, therefore, set out to investigate in vivo changes in presynaptic dopamine storage in patients with idiopathic Parkinson's disease as a function of the catechol-O-methyltransferase Val(158)Met polymorphism using (18)F-DOPA positron emission tomography.
|
22843413 |
2012 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease.
|
22083803 |
2012 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The COMT rs4680 and MAOB rs1799836 polymorphisms may increase susceptibility to PD risk among Japanese.
|
21781348 |
2011 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There were no global or local interactions between Parkinson's disease and COMT val(158)met genotype on morphometry.
|
18755526 |
2010 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Catechol-O-methyltransferase val158met and cognitive function in Parkinson's disease.
|
20878993 |
2010 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our previous work has implicated two genetic factors in the development of cognitive dysfunction in Parkinson's disease, namely the genes for catechol-O-methyltransferase (COMT Val(158)Met) and microtubule-associated protein tau (MAPT) H1/H2.
|
19812213 |
2009 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Attentional control in Parkinson's disease is dependent on COMT val 158 met genotype.
|
18178571 |
2008 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We scanned 31 patients with early PD who were homozygous for either valine (val) (n = 16) or methionine (met) (n = 15) at the COMT val(158)met polymorphism during performance of an executive task comprising both Tower of London (planning) and simple subtracting ("control") problems.
|
17475791 |
2007 |
|
rs4680
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease.
|
16453988 |
2006 |