Three SNPs were significantly associated with schizophrenia in samples (rs6039769, P = 6.64 × 10<sup>-7</sup>; rs3787283, P = 0.004283; rs3746544, P = 2.51 × 10<sup>-6</sup>).
The AG haplotype consisting of rs3787283 and rs3746544 was also significantly associated with both schizophrenia and major depressive disorder (schizophrenia: adjusted P = .0126; major depressive disorder: adjusted P = .000580).
We additionally genotyped a further 31 tag SNPs spanning the SNAP25 locus and identified several independent SNPs that were nominally associated with schizophrenia (strongest association at rs3787283, P = 0.006, OR = 1.25) however, due to the number of tests performed no SNP met experiment-wise significance (minimum permuted P-value = 0.1).