|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A preliminary study suggested that the COMTVal108/158Met genotype (rs4680) is related to cognitive function in schizophrenia.
|
30326466 |
2019 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the associations of rs4680 <i>COMT</i>, rs6280 <i>DRD3</i>, and rs7322347 <i>5HT2A</i> with youth-onset schizophrenia in the Russian population in a case-control study, and the role of the genotype in the severity of clinical features.
|
31798476 |
2019 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The <i>COMT</i> Val 108/158 Met polymorphism (rs4680) may affect treatment response to antipsychotics, as well as metabolism and dynamics of neurotransmitters during the treatment of schizophrenia.
|
29950847 |
2018 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results imply that PPI might be modulated by four genotypes - COMT rs4680 (primarily in males), GRIK3 rs1027599, TCF4 rs9960767, and PRODH rs385440 - indicating a role of these gene variations in the development of early information processing deficits in schizophrenia.
|
29287625 |
2018 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong association with neuroplasticity effect in schizophrenia.
|
29559020 |
2018 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Such associations of <i>COMT</i> rs4680 and rs4818 high-activity (G variants), as well as G-G/G-G haplotype, with the lower risk of TRS in females, but not in males, suggest significant, but sex-specific influence of <i>COMT</i> variants on the development of treatment-resistance in patients with schizophrenia.
|
30018555 |
2018 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, the methylation level of an rs4680-related CpG site was significantly associated with the Val/Val genotype which may contribute to the homicidal behavior of schizophrenia patients.
|
29455339 |
2018 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T and COMT Val158Met interact with CA to increase risk of schizophrenia.
|
28556887 |
2017 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found a significant association of rs737865, with the GG genotype exerting a protective effect and the GA haplotype (rs4680/rs165599) exerting a risk effect for schizophrenia.
|
28273278 |
2017 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Aggression behavior in patients with schizophrenia can be indicated by positive BOLD-fMRI values in the lower CNS and negative values in the high-level CNS and by a recessive gene model in <i>COMT</i> polymorphism rs4680.
|
28223811 |
2017 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
As impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (SERT 5-HTTLPR, MAO-A VNTR, COMT Val158Met and DAT VNTR) and schizophrenia.
|
28416295 |
2017 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Facial emotion recognition in schizophrenia: An exploratory study on the role of comorbid alcohol and substance use disorders and COMT Val158Met.
|
28913946 |
2017 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
No statistically significant correlations were recorded between age at schizophrenia onset and polymorphism of Val158Met COMT.
|
28856668 |
2017 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Executive control in schizophrenia: a preliminary study on the moderating role of COMT Val158Met for comorbid alcohol and substance use disorders.
|
28635556 |
2017 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In support of this notion, rich evidence has documented that the severity of various BD and schizophrenia symptoms is moderated by rs4680, a single nucleotide polymorphism of the COMT gene featuring a valine (Val)-to-methionine (Met) substitution that results in lower catalytic activity.
|
27458023 |
2017 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects.
|
27020768 |
2016 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Does COMT val158met polymorphism influence P50 sensory gating, eye tracking or saccadic inhibition dysfunctions in schizophrenia?
|
27825784 |
2016 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotypic variations in the functional polymorphism Val(158)Met COMT appear to have an impact in dopamine signaling in the PFC of healthy subjects and schizophrenia patients.
|
27421706 |
2016 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The COMT Val158Met polymorphism moderates the association between cognitive functions and white matter microstructure in schizophrenia.
|
26999687 |
2016 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the COMT Val158Met polymorphism is associated with response to antipsychotics in schizophrenia and schizo-affective disorder patients.
|
26745992 |
2016 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
COMT val158met polymorphism and molecular alterations in the human dorsolateral prefrontal cortex: Differences in controls and in schizophrenia.
|
27021555 |
2016 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We explored the relationship between fasting plasma proline levels and COMT Val(158)Met genotype on symptoms (positive, negative and total) in schizophrenia patients.
|
27622935 |
2016 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We report that the variation in gene sequence at the four COMT SNPs studied was not associated with an altered the risk of schizophrenia but genotype at rs4680 and rs4818, but not rs165519 and rs737865, were associated with varying levels of cortical CHRM1 expression in the human dorsolateral prefrontal cortex (DLPFC).
|
26954460 |
2016 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we explored the relationship between the Val158Met polymorphism of the COMT gene and the GMV/cortical thickness/cortical surface area in 150 first-episode treatment-naïve patients with schizophrenia and 100 healthy controls.
|
25564193 |
2015 |
|
rs4680
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional polymorphism of the catechol-O-methyltransferase (COMT) gene (Val158Met) partially appears to influence cognitive performance in schizophrenia subjects and healthy controls by modulating prefrontal dopaminergic activity.
|
26255563 |
2015 |